Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2024; 12(22): 5184-5188
Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5184
Glucocorticoid therapy in pancreatic portal hypertension associated with autoimmune pancreatitis: A case report
Yi Zhang, Zhao-Dong Li, Yuan-Jing He, Wei Peng, Yu-Jun Luo, Xiao-An Li
Yi Zhang, Zhao-Dong Li, Yuan-Jing He, Wei Peng, Yu-Jun Luo, Xiao-An Li, Department of Gastroenterology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China
Co-first authors: Yi Zhang and Zhao-Dong Li.
Author contributions: Zhang Y and Li ZD contributed equally to this work as co-first authors; Zhang Y and Li ZD contributed to manuscript writing and editing; Li ZD and He YJ treated the patient; Peng W, Luo YJ and Li XA reviewed the manuscript, data collection and searched the literature; All authors read and approved the final manuscript.
Supported by Sichuan Science and Technology Program, China, No. MZGC20230031.
Informed consent statement: All study participants had given their written informed consent for publication before participating in the current study. The patient was aware about the report and agreed to publish it.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-An Li, PhD, Professor, Department of Gastroenterology, Mianyang Central Hospital, No. 12 Jingzhong Road, Fucheng District, Mianyang 621000, Sichuan Province, China. 435445611@qq.com
Received: March 25, 2024
Revised: May 14, 2024
Accepted: June 11, 2024
Published online: August 6, 2024
Processing time: 99 Days and 23.7 Hours
Core Tip

Core Tip: Few studies have reported pancreatic portal hypertension (PPH) related to autoimmune pancreatitis (AIP). In our case, the complications of superior mesenteric vein and splenic vein thromboses, splenomegaly, and gastric varicose veins were observed with AIP. After 4 mo and 8 mo of glucocorticoid therapy, thrombus recanalization, disappearance of gastric varices (GV), and spleen shrinkage were observed. Glucocorticoid therapy may reduce the development and potential reversibility of GV in patients with AIP, and patients with PPH associated with AIP will benefit more from active steroid therapy. There remains controversy about the duration of hormone therapy, and long-term follow-up is required.