Park KH, Yoo JJ, Kim SG, Kim YS. Fatal intratumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab: A case report. World J Clin Cases 2024; 12(22): 5177-5183 [DOI: 10.12998/wjcc.v12.i22.5177]
Corresponding Author of This Article
Jeong-Ju Yoo, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Soonchunhyang University School of Medicine, 170 Jomaruro Wonmigu, Bucheonsi Gyeonggido, Bucheon 14584, South Korea.puby17@naver.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Aug 6, 2024; 12(22): 5177-5183 Published online Aug 6, 2024. doi: 10.12998/wjcc.v12.i22.5177
Fatal intratumoral hemorrhage in a patient with hepatocellular carcinoma following successful treatment with atezolizumab/bevacizumab: A case report
Kyeong-Hoon Park, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim
Kyeong-Hoon Park, Jeong-Ju Yoo, Sang Gyune Kim, Young Seok Kim, Department of Gastroenterology and Hepatology, Soonchunhyang University School of Medicine, Bucheon 14584, South Korea
Author contributions: Yoo JJ contributed to conceptualization and supervision; Park KH contributed to formal analysis; Kim SG and Kim YS contributed to investigation; Park KH contributed to manuscript writing; Yoo JJ contributed to manuscript review and editing; All authors have read and approved the final manuscript.
Supported bySoonchunhyang University Research Fund, No. 20240007.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and all accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jeong-Ju Yoo, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Soonchunhyang University School of Medicine, 170 Jomaruro Wonmigu, Bucheonsi Gyeonggido, Bucheon 14584, South Korea.puby17@naver.com
Received: March 14, 2024 Revised: May 28, 2024 Accepted: June 13, 2024 Published online: August 6, 2024 Processing time: 110 Days and 7.2 Hours
Core Tip
Core Tip: Our study delves into the emerging therapy of atezolizumab/bevacizumab for unresectable hepatocellular carcinoma (HCC), contrasting its efficacy with traditional treatments like sorafenib. We highlight the real-world challenges of bleeding complications, particularly intratumoral bleeding, associated with bevacizumab. Presenting a rare case, we emphasize the need for proactive measures, such as baseline examinations, to mitigate bleeding risks before initiating atezolizumab/bevacizumab. Our findings underscore the critical importance of vigilant monitoring and prompt intervention to address potentially fatal complications during atezolizumab/bevacizumab therapy, contributing to the evolving understanding of HCC treatment strategies.
