Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2024; 12(21): 4827-4835
Published online Jul 26, 2024. doi: 10.12998/wjcc.v12.i21.4827
Fifteen acute retrobulbar optic neuritis associated with COVID-19: A case report and review of literature
Rong-Rong Li, Bao-Ming Zhang, Su-Ran Rong, Huan Li, Peng-Fei Shi, Yun-Chang Wang
Rong-Rong Li, Bao-Ming Zhang, Su-Ran Rong, Huan Li, Peng-Fei Shi, Yun-Chang Wang, Hebei Provincial Key Laboratory of Ophthalmology, Hebei Provincial Clinical Research Center for Eye Diseases, Hebei Eye Hospital, Xingtai 054001, Hebei Province, China
Author contributions: Wang YC designed and conceptualized the research proposal; Zhang BM analyzed the data; Li RR wrote the paper; Li H, Shi PF and Rong SR collected the data and information; All authors gave their approval of the final manuscript after reviewing it.
Supported by Municipal Science and Technology Plan Project of Xingtai City, Hebei Province, No. 2022ZC232 and No. 2022ZC129.
Informed consent statement: This study was approved by the Medical Ethics Committee of Hebei Eye Hospital. Before beginning the study, all enrolled patients gave their informed consent to participate, according to the Declaration of Helsinki.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Chang Wang, MD, Doctor, Hebei Provincial Key Laboratory of Ophthalmology, Hebei Provincial Clinical Research Center for Eye Diseases, Hebei Eye Hospital, No. 399 East Quanbei Street, Xingtai 054001, Hebei Province, China. wycocular@163.com
Received: April 15, 2024
Revised: May 21, 2024
Accepted: June 11, 2024
Published online: July 26, 2024
Processing time: 76 Days and 11.5 Hours
Core Tip

Core Tip: Our study is the first to elucidate the relationship between the Omicron variant of severe acute respiratory syndrome coronavirus 2 and acute retrobulbar optic neuritis in China, which may be attributed to two main factors: Immune involvement in the process and direct viral infiltration of the central nervous system. In addition, hypoxia and ischemia may be associated with the appearance of this disease. Further investigation is needed to gain a more complete picture of this relationship.