Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2024; 12(20): 4348-4356
Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4348
Pulsatile gonadotropin-releasing hormone therapy induces spermatogenesis in pituitary stalk interruption syndrome: A case report and review of the literature
Jin-Long Xie, Hai-Ying Zhu, Yang Dong, Ping-Ping Sun, Dan-Dan Qi, Su-Xian Luan, Yan Zhang, Hua-Gang Ma
Jin-Long Xie, Hai-Ying Zhu, Ping-Ping Sun, Dan-Dan Qi, Su-Xian Luan, Yan Zhang, Hua-Gang Ma, The Reproductive Medicine Centre, Weifang People's Hospital, Weifang 261000, Shandong Province, China
Yang Dong, Department of Radiology, Weifang People's Hospital, Weifang 261000, Shandong Province, China
Author contributions: Ma HG and Xie JL contributed to conceptualization; Xie JL, Zhu HY, Dong Y, Qi DD, and Luan SX contributed to data curation; Xie JL and Zhu HY contributed to formal analysis; Xie JL and Sun PP contributed to investigation; Xie JL and Zhang Y contributed to software; Ma HG contributed to supervision; Xie JL, Zhu HY, Dong Y, Sun PP, Qi DD, Luan SX, Zhang Y, and Ma HG contributed to validation; Xie JL contributed to writing of the original draft; Xie JL, Ma HG, Zhu HY, Dong Y, Sun PP, Qi DD, Luan SX, and Zhang Y contributed to manuscript review & editing.
Supported by Weifang Fundamental Research Projects, No. WFWSJK-2023-052.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this case report and the accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua-Gang Ma, PhD, Professor, The Reproductive Medicine Centre, Weifang People’s Hospital, No. 151 Guangwen Street, Weifang 261000, Shandong Province, China. mahuagang@126.com
Received: March 7, 2024
Revised: May 18, 2024
Accepted: June 4, 2024
Published online: July 16, 2024
Processing time: 114 Days and 18.4 Hours
Core Tip

Core Tip: Pituitary stalk interruption syndrome (PSIS) is a rare anatomical defect affecting the pituitary gland, falling within the spectrum of holoprosencephaly phenotypes. In cases where fertility is a concern, treatment options typically involve pulsatile gonadotropin-releasing hormone (GnRH) therapy and gonadotropin therapy. This case study highlights a patient with PSIS who initially did not respond to gonadotropin therapy but showed successful spermatogenesis upon switching to pulsatile GnRH therapy. Timely identification, accurate diagnosis, and tailored treatment play a vital role in enhancing the quality of life and fertility outcomes for individuals with PSIS.