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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2024; 12(20): 4146-4153
Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4146
Published online Jul 16, 2024. doi: 10.12998/wjcc.v12.i20.4146
Correlation analysis of human papillomavirus E6/E7 mRNA detection with diagnosis, prognosis and recurrence risk in patients with cervical epithelioma
Ling-Li Zhang, Xin Du, Jie Duan, Dong-Mei Yao, Jing Jing, Chun Feng, Department of Gynaecology, Maternal and Child Health Hospital of Hubei Province, Wuhan 430075, Hubei Province, China
Ming-Yan Du, Department of Gynaecology, China Resources WISCO General Hospital, Wuhan 430080, Hubei Province, China
Lin Song, Department of Surgery, Maternal and Child Health Hospital of Hubei Province, Wuhan 430075, Hubei Province, China
Author contributions: Zhang LL and Du MY designed the research; Du X, Duan J, Yao DM, Jin J and Feng C contributed new reagents/analytic tools; Song L analyzed the data; Zhang LL and Du MY wrote the paper.
Supported by Scientific Research Project of Hubei Provincial Health Commission , No. WJ2021M189 .
Institutional review board statement: This study protocol was approved by Maternal and child health hospital of Hubei Province, and all the families have voluntarily participated in the study and have signed informed consent forms.
Informed consent statement: We explained the purpose, process, risks and benefits of the study to all individuals involved in the study orally or in writing, and obtained their informed consent. Participants have the right to know that their participation is voluntary and can withdraw from the study at any time.
Conflict-of-interest statement: The authors declared no conflict of interest existing in this paper.
Data sharing statement: Data generated from this investigation are available upon reasonable request from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lin Song, MM, Doctor, Department of Surgery, Maternal and Child Health Hospital of Hubei Province, No. 745 Wuluo Road, Hongshan District, Wuhan 430075, Hubei Province, China. linsoweet@163.com
Received: April 8, 2024
Revised: May 13, 2024
Accepted: May 20, 2024
Published online: July 16, 2024
Processing time: 83 Days and 15.9 Hours
Revised: May 13, 2024
Accepted: May 20, 2024
Published online: July 16, 2024
Processing time: 83 Days and 15.9 Hours
Core Tip
Core Tip: In this study, cervical cancer is a common gynecological malignancy, its incidence is increasing year by year, and human papillomavirus (HPV) infection is closely related to the occurrence and development of cervical cancer. Cervical intraepithelial neoplasia (CIN) is an important precursor to cervical cancer development, and early detection and treatment can reduce the incidence of cervical cancer. We plan to use RNA-seq technology to detect the expression level of HPV E6/E7 mRNA in cervical cancer tissues of CIN patients, and for correlation with the diagnosis, prognosis, recurrence, and other factors of CIN patients, to provide new ideas for the follow-up and treatment of CIN patients.