Ni HY, Zhang YP, Zhang XF. Therapeutic effect of San Bi Tang combined with glucosamine sulfate capsules in cold-dampness-type knee osteoarthritis. World J Clin Cases 2024; 12(19): 3854-3865 [PMID: 38994299 DOI: 10.12998/wjcc.v12.i19.3854]
Corresponding Author of This Article
Xiao-Feng Zhang, BMed, Associate Chief Physician, Department of Orthopedics and Traumatology, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, No. 418 Fengpu Road, Fuchun Street, Fuyang District, Hangzhou 311400, Zhejiang Province, China. zh1x2f3@163.com
Research Domain of This Article
Orthopedics
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 6, 2024; 12(19): 3854-3865 Published online Jul 6, 2024. doi: 10.12998/wjcc.v12.i19.3854
Therapeutic effect of San Bi Tang combined with glucosamine sulfate capsules in cold-dampness-type knee osteoarthritis
Hui-Ying Ni, Yao-Ping Zhang, Xiao-Feng Zhang
Hui-Ying Ni, Yao-Ping Zhang, Xiao-Feng Zhang, Department of Orthopedics and Traumatology, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, Hangzhou 311400, Zhejiang Province, China
Author contributions: Ni HY designed the study; Zhang YP performed the data collection and analysed the data; and Zhang XF wrote the manuscript; All authors reviewed the manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, No. 2020-LW-LC-001.
Informed consent statement: The data utilized in this study did not involve any personally identifiable information of the patients. All patient data collected, recorded, and managed were strictly for the purposes of this study and did not compromise patient welfare in any way. Therefore, the requirement for informed consent was waived by the Ethics Committee of Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data for this study were obtained by contacting the corresponding author.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Feng Zhang, BMed, Associate Chief Physician, Department of Orthopedics and Traumatology, Hangzhou Fuyang Hospital of TCM Orthopedics and Traumatology, No. 418 Fengpu Road, Fuchun Street, Fuyang District, Hangzhou 311400, Zhejiang Province, China. zh1x2f3@163.com
Received: April 8, 2024 Revised: May 11, 2024 Accepted: May 20, 2024 Published online: July 6, 2024 Processing time: 81 Days and 21.4 Hours
Core Tip
Core Tip: This study evaluates the effectiveness and safety of modified San Bi Tang combined with glucosamine sulfate capsules in treating cold dampness type knee osteoarthritis (KO). It reveals that this combination therapy significantly improves pain, knee joint function, and traditional Chinese medicine (TCM)-specific symptoms compared to glucosamine sulfate alone. Utilizing visual simulation scores, osteoarthritis index scores, and functional tests, the research highlights the superior clinical efficacy of the combined treatment. Safety assessments indicate no adverse impacts on liver and kidney functions, suggesting a high safety profile. These findings advocate for the integration of TCM with conventional treatments in KO management, offering a promising alternative for patients seeking relief from osteoarthritis symptoms.
