Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2024; 12(19): 3845-3853
Published online Jul 6, 2024. doi: 10.12998/wjcc.v12.i19.3845
Prognostic role of the stromal cell derived factor-1 in patients with hepatitis B virus-related acute-on-chronic liver failure
Li Zhang, Jian-Yu Wang, Cai-Yan Zhao, Chuan Shen, Mei-Ru Chen, Zhi-Ying Tian
Li Zhang, Mei-Ru Chen, Zhi-Ying Tian, Department of Gastroenterology, Hengshui People's Hospital, Hengshui 053000, Hebei Province, China
Jian-Yu Wang, Department of Neurology, Hengshui People's Hospital, Hengshui 053000, Hebei Province, China
Cai-Yan Zhao, Chuan Shen, Department of Infection, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Author contributions: Tian ZY designed the study; Wang JY, Zhao CY, Shen C, Chen MR performed the data collection and analysed the data; and Zhang L wrote the manuscript; All authors reviewed the manuscript.
Supported by Science and Technology Project of Hengshui, No. 2019014061Z.
Institutional review board statement: This study was reviewed by the Ethics Committee of the Third Affiliated Hospital of Hebei Medical University, 2021-3-021.
Informed consent statement: The study exclusively utilized anonymized patient data, ensuring no invasion of personal privacy. All patient data were collected, recorded, and managed strictly for research purposes within this study, posing no risk to the participants. Consequently, the ethics committee of the Third Affiliated Hospital of Hebei Medical University has granted a waiver for informed consent.
Conflict-of-interest statement: All authors declare that there is no conflict of interest in this study.
Data sharing statement: Please contact the corresponding author for original data.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Ying Tian, MD, Associate Chief Physician, Department of Gastroenterology, Hengshui People's Hospital, No. 180 Renmin East Road, Hengshui 053000, Hebei Province, China. hshy2024@163.com
Received: March 9, 2024
Revised: May 7, 2024
Accepted: May 13, 2024
Published online: July 6, 2024
Processing time: 111 Days and 23.3 Hours
Core Tip

Core Tip: In this study, we investigated the changes in stromal cell derived factor-1 (SDF-1) in hepatitis B virus (HBV) associated acute-on-chronic liver failure (ACLF) patients. 30 HBV related ACLF patients, 27 chronic hepatitis B patients, and 20 healthy participants participated in our study. Our research findings provide information on the changes in SDF-1 in HBV associated ACLF patients. The level of SDF-1 at admission can serve as a promising prognostic marker for predicting short-term prognosis.