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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 26, 2024; 12(18): 3428-3437
Published online Jun 26, 2024. doi: 10.12998/wjcc.v12.i18.3428
Published online Jun 26, 2024. doi: 10.12998/wjcc.v12.i18.3428
Association of total bilirubin with depression risk in adults with diabetes: A cross-sectional study
Man-Li Ye, Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Jie-Ke Wang, Department of Hand and Plastic Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Wang JK analyzed and interpreted the data; Ye ML wrote the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: The study was conducted in accordance with the Declaration of Helsinki, and approved by the National Center for Health Statistics Institutional Review Board/Ethics Review Board (NCHS IRB/ERB).
Informed consent statement: Informed consent was obtained from all subjects involved in the study.
Conflict-of-interest statement: The authors declare that they have no competing interests in this section.
Data sharing statement: The datasets analyzed in this study can be found on the NHANES website, available here: https://www.cdc.gov/nchs/nhanes/.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Man-Li Ye, MD, MSc, Chief Technician, Department of Laboratory Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 Xueyuanxi Road, Lucheng District, Wenzhou 325000, Zhejiang Province, China. aikoye1207@126.com
Received: March 10, 2024
Revised: April 30, 2024
Accepted: May 17, 2024
Published online: June 26, 2024
Processing time: 100 Days and 1.6 Hours
Revised: April 30, 2024
Accepted: May 17, 2024
Published online: June 26, 2024
Processing time: 100 Days and 1.6 Hours
Core Tip
Core Tip: Diabetic adults with lower total bilirubin levels had a higher risk of depression. We adjusted for confounders that might affect the association between total bilirubin and depression risk by analyzing the detailed covariate data. After propensity score matching, this association was further confirmed. Subgroup analyses illustrated that there was no significant dependence of age, body mass index, gender, race and hypertension on this association. Restricted cubic spline models displayed an inverted U-shaped association of total bilirubin with depression risk within the lower range of total bilirubin.