Sanyal D, Mukhopadhyay P, Ghosh S. Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis. World J Clin Cases 2024; 12(18): 3332-3339 [PMID: 38983439 DOI: 10.12998/wjcc.v12.i18.3332]
Corresponding Author of This Article
Debmalya Sanyal, FACE, Professor, Department of Endocrinology, KPC Medical College, 1F, Raja SC Mallick Road, Jadavpur, Kolkata 700032, West Bengal, India. drdebmalyasanyal@gmail.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2024; 12(18): 3332-3339 Published online Jun 26, 2024. doi: 10.12998/wjcc.v12.i18.3332
Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis
Debmalya Sanyal, Pradip Mukhopadhyay, Sujoy Ghosh
Debmalya Sanyal, Department of Endocrinology, NHRTIICS & KPC Medical College, Kolkata 700032, West Bengal, India
Pradip Mukhopadhyay, Department of Endocrinology, IPGME&R and SSKM Hospital, Kolkata 700020, West Bengal, India
Sujoy Ghosh, Department of Endocrinology, IPGME&R, Kolkata 700020, West Bengal, India
Author contributions: Sanyal D conceptualized and conducted the study; Sanyal D and Mukhopadhyay P conducted the data analysis, literature search and developed the manuscript draft; Sanyal D, Mukhopadhyay P and Ghosh S contributed to critically reviewing and revision of the manuscript. All authors have read and approved the final manuscript.
Institutional review board statement: The study has been carried out in accordance with the Institutional Review Board of Ethics (EC Ref No. KNRTIICSEC/INV/Non-Reg/2022/004).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: The presented data are anonymized and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Debmalya Sanyal, FACE, Professor, Department of Endocrinology, KPC Medical College, 1F, Raja SC Mallick Road, Jadavpur, Kolkata 700032, West Bengal, India. drdebmalyasanyal@gmail.com
Received: December 30, 2023 Revised: February 6, 2024 Accepted: May 8, 2024 Published online: June 26, 2024 Processing time: 170 Days and 17.2 Hours
Core Tip
Core Tip: Current investigation found a high prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in primary hyperaldosteronism (PH) at diagnosis. However glycaemic status did not impact clinical or biochemical profiles, number of antihypertensive medications or complications. Long duration of hypertension, high antihypertensive requirement and hypokalemia with hypertension was the most common presentation, suggesting delayed PH diagnosis irrespective of glycaemic status. Underlying undetected PH can worsen hypertension, glycemia and cardiorenal risk in hypertensive patients with T2DM/prediabetes. Screening and early detection of PH in T2DM/prediabetes subjects with hypertension especially with hypokalemia or resistant hypertension, might help in effective management and preventing complications of hypertension and uncontrolled T2DM.
