Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2024; 12(17): 3271-3276
Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3271
Treatment of primary nasal tuberculosis with anti-tumor necrosis factor immunotherapy: A case report
Yong-Cai Liu, Min-Li Zhou, Ke-Jia Cheng, Shui-Hong Zhou, Xue Wen
Yong-Cai Liu, Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, HangZhou 310003, Zhejiang Province, China
Min-Li Zhou, Ke-Jia Cheng, Shui-Hong Zhou, Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Xue Wen, Department of Pathology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Liu YC contributed to data collection, paper review, initial manuscript writing and editing; Liu YC, Cheng KJ, and Zhou SH contributed to conceptualization, final manuscript draft and corrections; Liu YC, Zhou ML, Cheng KJ, and Wen X contributed to clinical examination, surgery, and patient follow up; All authors have read and agreed to the published version of the final manuscript.
Supported by Department of Health of Zhejiang Province, No. 2019-KY1-001-138; and Zhejiang Provincial Natural Science Foundatio, No. LTGY24H160016.
Informed consent statement: Consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ke-Jia Cheng, MD, Chief Doctor, Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. 1505026@zju.edu.cn
Received: March 10, 2024
Revised: April 24, 2024
Accepted: May 6, 2024
Published online: June 16, 2024
Processing time: 86 Days and 3.9 Hours
Core Tip

Core Tip: Primary nasal tuberculosis is a rare form of extrapulmonary tuberculosis (TB), particularly in patients receiving anti-tumor necrosis factor immunotherapy. The nasal cavity is most commonly involved; most infections involve the nasal septum and/or the inferior turbinate. We should remain vigilant for primary nasal TB in patients treated with tumor necrosis factor antagonists if the nasal mucosa of the nasal septum or the inferior turbinate demonstrates thickening or crusting, particularly when pathological findings suggest granulomatous inflammation. For suspected cases, repeated biopsies may enhance the identification of acid-fast bacilli.