Chow MBCY, Bushrow L, Siddiqui I, Chiu A, Hamirani M, Satoskar AA. Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining - another cause for diagnostic overlap: A case report. World J Clin Cases 2024; 12(17): 3200-3205 [PMID: 38898862 DOI: 10.12998/wjcc.v12.i17.3200]
Corresponding Author of This Article
Anjali A Satoskar, MD, Professor, Department of Pathology, The Ohio State University Medical Center, B073 Graves Hall 333 W 10th Ave, Columbus, OH 43210, United States. anjali.satoskar@osumc.edu
Research Domain of This Article
Pathology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 16, 2024; 12(17): 3200-3205 Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3200
Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining - another cause for diagnostic overlap: A case report
Maria Bernadette Che-Ying Chow, Lucas Bushrow, Irmeen Siddiqui, April Chiu, Mirza Hamirani, Anjali A Satoskar
Maria Bernadette Che-Ying Chow, Lucas Bushrow, Irmeen Siddiqui, Anjali A Satoskar, Department of Pathology, The Ohio State University Medical Center, Columbus, OH 43210, United States
Maria Bernadette Che-Ying Chow, Department of Pathology, North District Hospital, Sheung Shui, Hong Kong, China
April Chiu, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, United States
Mirza Hamirani, Department of Internal Medicine, S. Joseph's Hospital, Parkersburg, WV 26101, United States
Author contributions: Chow MBCY drafted and revised the manuscript; Bushrow L helped draft the manuscript; Siddiqui I helped with serum immunofixation results; Chiu A provided mass spectrometry result and Figure 2; Hamirani H provided clinical follow-up and obtained patient consent; Satoskar AA conceptualized and the idea and implemented the collaborative effort, drafted and revised the manuscript, and provided immunofluorescence images.
Informed consent statement: Study participant provided informed written consent prior to study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anjali A Satoskar, MD, Professor, Department of Pathology, The Ohio State University Medical Center, B073 Graves Hall 333 W 10th Ave, Columbus, OH 43210, United States. anjali.satoskar@osumc.edu
Received: February 6, 2024 Revised: March 15, 2024 Accepted: April 23, 2024 Published online: June 16, 2024 Processing time: 118 Days and 16.2 Hours
Core Tip
Core Tip: Amyloidosis and fibrillary glomerulonephritis are the two most commonly encountered glomerulopathies with fibrillary deposits. Accurate diagnosis and differentiation between these two entities are important for patient management. Furthermore, accurate subtyping is also required for amyloidosis cases to further guide treatment. This case report highlights an uncommon diagnostic pitfall that a nephropathologist may encounter while distinguishing light and heavy chain amyloid from fibrillary glomerulopathy. The possible underlying mechanisms are discussed, and we reiterate the importance of a clinical-pathological correlation and the use of multiple available diagnostic modalities if needed, particularly for these overlapping diagnostic entities.
