Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2024; 12(17): 3094-3104
Published online Jun 16, 2024. doi: 10.12998/wjcc.v12.i17.3094
Immune cell signatures and causal association with irritable bowel syndrome: A mendelian randomization study
Wei-Hao Chai, Yan Ma, Jia-Jia Li, Fei Guo, Yi-Zhan Wu, Jiang-Wei Liu
Wei-Hao Chai, Yi-Zhan Wu, Department of Graduate School, Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Yan Ma, Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
Jia-Jia Li, Jiang-Wei Liu, Key Laboratory of Special Environmental Medicine of Xinjiang, General Hospital of Xinjiang Military Command of the PLA, Urumqi 830000, Xinjiang Uygur Autonomous Region, China
Fei Guo, Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
Co-first authors: Wei-Hao Chai and Yan Ma.
Author contributions: Chai WH and Ma Y contributed equally to this work; Chai WH, Ma Y, Liu JW, and Li JJ designed the research study; Chai WH, Ma Y, and Guo F performed the research; Chai WH, Ma Y and Wu YZ analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Conflict-of-interest statement: The author declares that there were no commercial or financial conflicts of interest during the execution of this study. The author has not received any funding or other forms of sponsorship directly related to this study from any organization or individual. In addition, the author declares that there are no patents, copyrights, or other intellectual property rights, and there are no non-financial conflicts of interest related to this study.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jiang-Wei Liu, PhD, Chief Doctor, Key Laboratory of Special Environmental Medicine of Xinjiang, General Hospital of Xinjiang Military Command of the PLA, No. 359 Youhao North Road, Urumqi 830000, Xinjiang Uygur Autonomous Region, China. ljw273273@163.com
Received: December 18, 2023
Revised: February 10, 2024
Accepted: April 29, 2024
Published online: June 16, 2024
Processing time: 169 Days and 4.5 Hours
Core Tip

Core Tip: Our investigation has uncovered a substantial genetic link between immune cell phenotypes and irritable bowel syndrome (IBS), offering critical insights into the disease's pathophysiological underpinnings. This finding is pivotal for advancing our comprehension of IBS and paves the way for innovative diagnostic and therapeutic strategies. Moreover, this knowledge contributes to the development of more precise biomarkers and treatment modalities tailored to IBS, potentially leading to more efficacious personalized care plans for patients. These advancements are anticipated to enhance the quality of life for individuals suffering from IBS and alleviate the disease's burden on patients and their families.