Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2024; 12(16): 2803-2812
Published online Jun 6, 2024. doi: 10.12998/wjcc.v12.i16.2803
Iron and ferritin effects on intensive care unit mortality: A meta-analysis
Deng-Can Yang, Bo-Jun Zheng, Jian Li, Yi Yu
Deng-Can Yang, Department of Anesthesiology, The Central Hospital of Shaoyang, Shaoyang 422000, Hunan Province, China
Bo-Jun Zheng, Jian Li, Department of Critical Care Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Yi Yu, Department of Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Author contributions: Yu Y and Zheng BJ designed and acquired the data; Yang DC analyzed and interpreted the data; Li J drafted the article and revising it critically for important intellectual content; Yu Y final approval of the version to be published.
Supported by The National Natural Science Foundation of China, No. 82104989.
Conflict-of-interest statement: The authors declare that they have no competing interests.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi Yu, Doctor, Doctor, Research Scientist, Department of Critical Care Medicine, Guangdong Provincial Hospital of Traditional Chinese Medicine, No. 55 Neihuan Xilu, Daxuecheng, Guangzhou 510006, Guangdong Province, China. 1191922959@qq.com
Received: February 19, 2024
Revised: March 7, 2024
Accepted: April 11, 2024
Published online: June 6, 2024
Processing time: 99 Days and 20 Hours
Core Tip

Core Tip: This systematic review presents evidence of a negative correlation between serum iron levels and mortality among patients with sepsis. Furthermore, it reveals a minor yet adverse impact of serum ferritin on mortality among the United States population. This guide provides direction for future prognostic assessments in patients with sepsis. Further high-quality cohort studies and experimental studies on molecular mechanisms are needed to confirm our findings.