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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2024; 12(16): 2789-2795
Published online Jun 6, 2024. doi: 10.12998/wjcc.v12.i16.2789
Published online Jun 6, 2024. doi: 10.12998/wjcc.v12.i16.2789
Causal association between 25-hydroxyvitamin D status and cataract development: A two-sample Mendelian randomization study
Chun-Hui Wang, Zhi-Kun Xin, Department of Ophthalmology, Aviation General Hospital, Beijing 100010, China
Author contributions: Wang CH contributed to research design, data collection, interpretation, analysis, and manuscript drafting; Xin ZK contributed to result interpretation and critical revision of the manuscript; all authors approved the final version and agree to be accountable for all aspects of the work.
Conflict-of-interest statement: There is no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Kun Xin, BMed, Chief Physician, Department of Ophthalmology, Aviation General Hospital, No. 3 Anwai Beiyuan Courtyard, Anli Road, Chaoyang District, Beijing 100010, China. xzkavic@163.com
Received: March 10, 2024
Revised: April 23, 2024
Accepted: April 28, 2024
Published online: June 6, 2024
Processing time: 79 Days and 23.9 Hours
Revised: April 23, 2024
Accepted: April 28, 2024
Published online: June 6, 2024
Processing time: 79 Days and 23.9 Hours
Core Tip
Core Tip: Previous studies have documented the role of vitamin D in cataract development, yet investigations into the causal relationship between 25-(OH)D status and cataract onset are still lacking. Using Mendelian randomization, our study established a significant association between elevated 25-(OH)D levels and increased cataract risk. Additionally, a search of the human genotype-phenotype association database revealed no potentially relevant risk-factor single nucleotide polymorphisms. These findings need to be verified by further experiments.