Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2024; 12(15): 2655-2663
Published online May 26, 2024. doi: 10.12998/wjcc.v12.i15.2655
Transformation of marginal zone lymphoma into high-grade B-cell lymphoma expressing terminal deoxynucleotidyl transferase: A case report
Zhi-Min Fan, Dao-Lei Wu, Neng-Wen Xu, Li Ye, Li-Ping Yan, Lin-Jie Li, Jun-Yu Zhang
Zhi-Min Fan, Neng-Wen Xu, Lin-Jie Li, Jun-Yu Zhang, Department of Hematology, Lishui Municipal Central Hospital, Lishui 323000, Zhejiang Province, China
Dao-Lei Wu, Department of Ophthalmology, Lishui Municipal Central Hospital, Lishui 323000, Zhejiang Province, China
Li Ye, Department of General Practice, Lishui Municipal Central Hospital, Lishui 323000, Zhejiang Province, China
Li-Ping Yan, Department of Pathology, Lishui Municipal Central Hospital, Lishui 323000, Zhejiang Province, China
Author contributions: Fan ZM and Wu DL contributed equally to this work; Fan ZM and Wu DL wrote the first draft of the manuscript; Yan LP participation in pathological analysis; Xu NW, Ye L, Li LJ and Zhang JY revised the manuscript. All authors have read and approve the final manuscript.
Supported by The Lishui Science and Technology Planing Projects, No. 2020SJZC048.
Informed consent statement: The patient’s daughter and wife provided written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dao-Lei Wu, MMed, Attending Doctor, Department of Ophthalmology, Lishui Municipal Central Hospital, No. 289 Kuocang Road, Lishui 323000, Zhejiang Province, China. zxnhh1967@163.com
Received: February 8, 2024
Revised: March 15, 2024
Accepted: April 9, 2024
Published online: May 26, 2024
Processing time: 96 Days and 1.4 Hours
Core Tip

Core Tip: Marginal zone lymphoma (MZL) are a group of B-cell malignant neoplastic diseases with the most common transformation to diffuse large B-cell lymphoma. Herein, we report one rare case of MZL converted to high-grade B-cell lymphoma, not otherwise specific (HGBL-NOS) and concomitant terminal deoxynucleotidyl transferase expression in a 63-year-old male for the first time. HGBL-NOS often has a poor prognosis. The current treatment advocates high-dose chemotherapy, but there is currently no effective treatment for patients who cannot tolerate chemotherapy. We have attempted targeted pharmacological combinations and achieved certain therapeutic effects, which may provide new treatment for these patients.