Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2024; 12(15): 2636-2641
Published online May 26, 2024. doi: 10.12998/wjcc.v12.i15.2636
Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis: A case report
Zhi-Yun Weng, Wen-Ye Huang, Bin-Kan Shi, Jian-Jia Pan
Zhi-Yun Weng, Wen-Ye Huang, Bin-Kan Shi, Jian-Jia Pan, Department of Hematology, The Affiliated Yueqing Hospital of Wenzhou Medical University, Yueqing 325600, Zhejiang Province, China
Co-first authors: Zhi-Yun Weng and Wen-Ye Huang.
Author contributions: Weng ZY provided direction and guidance throughout the preparation of this manuscript; Huang WY drafted the paper; Shi BK contributed to data analysis; Pan JJ made critical revisions related to important intellectual content of the manuscript; Weng ZY and Huang WY contributed equally to the manuscript; All authors have read and approved the final manuscript.
Informed consent statement: Written consent was obtained from the patient’s family to participate in the study.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Zhi-Yun Weng, PhD, Chief Doctor, Department of Hematology, The Affiliated Yueqing Hospital of Wenzhou Medical University, No. 338 Qingyuan Road, Yueqing 325600, Zhejiang Province, China. weng_zhi_yun@163.com
Received: January 30, 2024
Revised: February 14, 2024
Accepted: April 7, 2024
Published online: May 26, 2024
Core Tip

Core Tip: Common metastatic sites for gastric adenocarcinoma (GaC) occur in the lymph nodes, liver, and lungs. Additionally, brain metastases (BM) are rare. Interestingly, mesenchymal epithelial transition factor receptor (MET) amplification in GaC is rare, and its role in tumor metastasis remains unclear. Several previous reports have described the association between MET amplification and BM with GaC. This case highlights the unique phenomenon of rapid BM in advanced GaC after first-line treatment and the rapid short-term reduction of cerebellar metastases after the use of savolitinib. Therefore, it is hypothesized that MET amplification may be a key driver of BMs in GaC.