Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 6, 2024; 12(13): 2160-2172
Published online May 6, 2024. doi: 10.12998/wjcc.v12.i13.2160
Detection and analysis of serum bile acid profile in patients with colonic polyps
Xin Ji, Hong Chen
Xin Ji, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China
Hong Chen, Department of Gastroenterology, Zhongda Hospital Southeast University, Nanjing 210009, Jiangsu Province, China
Author contributions: Ji X and Chen H provided the conception and design of the research; Ji X collected and analyzed the data, wrote the manuscript.
Institutional review board statement: This study was reviewed and approved by the Zhongda Hospital Institutional Review Board (Approval No.2021ZDSYLL297-P01).
Informed consent statement: This study was a retrospective study that collected existing clinical data from relevant populations through the hospital's electronic case system for statistical analysis. Therefore, we apologize that we are unable to provide informed consent.
Conflict-of-interest statement: All authors have no conflicts of interest to disclose.
Data sharing statement: Data supporting the research article are available from the corresponding author or first author on reasonable request.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Chen, Doctor, Professor, Department of Gastroenterology, Zhongda Hospital Southeast University, No. 87 Dingjiaqiao, Gulou District, Nanjing 210009, Jiangsu Province, China. njchenhong66@163.com
Received: December 14, 2023
Peer-review started: December 14, 2023
First decision: February 12, 2024
Revised: February 21, 2024
Accepted: March 28, 2024
Article in press: March 28, 2024
Published online: May 6, 2024
Core Tip

Core Tip: This study shows that the serum primary conjugated bile acid (BA) levels in the colonic polyp group were significantly higher than those in the control group (P < 0.05), while the secondary free BA, deoxycholic acid content was lower than that in the control group. Patients with various polyp sizes, locations, morphologies, and pathological types had variable serum BA profile, according to subgroup study of colonic polyps. Therefore, analyzing the changes in serum BA profile may provide new ideas for finding new targets for the treatment of colonic tumors.