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World J Clin Cases. Apr 26, 2024; 12(12): 2031-2039
Published online Apr 26, 2024. doi: 10.12998/wjcc.v12.i12.2031
Autoantibodies related to ataxia and other central nervous system manifestations of gluten enteropathy
Tsvetelina Velikova, Georgi Vasilev, Russka Shumnalieva, Lyubomir Chervenkov, Dimitrina Georgieva Miteva, Milena Gulinac, Stamatios Priftis, Snezhina Lazova
Tsvetelina Velikova, Georgi Vasilev, Russka Shumnalieva, Dimitrina Georgieva Miteva, Milena Gulinac, Snezhina Lazova, Medical Faculty, Sofia University "St. Kliment Ohridski", Sofia 1407, Bulgaria
Georgi Vasilev, Clinic of Neurology and Department of Emergency Medicine, UMHAT "Sv. Georgi", Plovdiv 4000, Bulgaria
Russka Shumnalieva, Department of Rheumatology, Clinic of Rheumatology, University Hospital "St. Ivan Rilski", Medical University-Sofia, Sofia 1612, Bulgaria
Lyubomir Chervenkov, Department of Diagnostic Imaging, Medical University Plovdiv, Plovdiv 4000, Bulgaria
Dimitrina Georgieva Miteva, Department of Genetics, Faculty of Biology, Sofia University "St. Kliment Ohridski", Sofia 1164, Bulgaria
Milena Gulinac, Department of General and Clinical Pathology, Medical University of Plovdiv, Plovdiv 4002, Bulgaria
Stamatios Priftis, Snezhina Lazova, Department of Healthcare, Faculty of Public Health “Prof. Tsekomir Vodenicharov, MD, DSc”, Medical University of Sofia, Sofia 1407, Bulgaria
Snezhina Lazova, Department of Pediatric, University Hospital "N. I. Pirogov", Sofia 1606, Bulgaria
Author contributions: Velikova T, Vasilev G and Lazova S contributed to conceptualization; Gulinac M and Chervenkov L contributed to investigation; Miteva DG, Priftis S and Shumnalieva R contributed to resources; Vasilev G, Shumnalieva R and Miteva DG contributed to data curation; Velikova T and Miteva DG contributed to visualization; Velikova T, Vasilev G and Shumnalieva R contributed to writing and original draft preparation; Chervenkov L, Gulinac M and Lazova S contributed to writing, review and editing; Velikova T contributed to supervision. All authors revised and approved the final version of the paper prior to submission.
Supported by The European Union-NextGenerationEU, Through The National Recov-ery and Resilience Plan of the Republic of Bulgaria, No. BG-RRP-2.004-0008.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Georgi Vasilev, MD, Chief Physician, Clinic of Neurology and Department of Emergency Medicine, UMHAT "Sv. Georgi", Blvd. Peshtersko shose 66, Plovdiv 4000, Bulgaria. vvasilev.georgi@gmail.com
Received: December 30, 2023
Peer-review started: December 30, 2023
First decision: January 16, 2024
Revised: February 7, 2024
Accepted: March 26, 2024
Article in press: March 26, 2024
Published online: April 26, 2024
Core Tip

Core Tip: Crucial insights into the complex nexus between gluten enteropathy and neurological disorders underscore the significance of specific autoantibodies. Anti-gliadin, anti-transglutaminase 2, anti-glycine receptor, anti-glutamine acid decarboxylase, and anti-deamidated gliadin peptides antibodies emerge as pivotal biomarkers, linking conditions from the gluten spectrum to diverse neurological manifestations. The prevalence of these antibodies in patients with gluten enteropathy and associated neurological dysfunction offers a diagnostic compass. Furthermore, the transformative impact of a gluten-free diet on clinical outcomes highlights its therapeutic relevance.