Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jan 6, 2024; 12(1): 157-162
Published online Jan 6, 2024. doi: 10.12998/wjcc.v12.i1.157
Successful management of severe hypoglycemia induced by total parenteral nutrition in patients with hepatocellular injury: Three cases reports
Ling-Zhi Fang, Hui-Xin Jin, Na Zhao, Yu-Pei Wu, Ying-Qin Shi
Ling-Zhi Fang, Hui-Xin Jin, Na Zhao, Yu-Pei Wu, Ying-Qin Shi, Department of Pharmacy, Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China
Author contributions: Fang LZ and Shi YQ contributed to the conception and design of the research; Jin HX and Zhao N contributed to analysis of the data; Wu YP contributed to manuscript preparation; All authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ling-Zhi Fang, MSc, Pharmacist, Department of Pharmacy, Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, No. 348 Heping West Road, Xinhua District, Shijiazhuang 050051, Hebei Province, China. fanglingzhi99@163.com
Received: September 7, 2023
Peer-review started: September 7, 2023
First decision: November 1, 2023
Revised: November 7, 2023
Accepted: December 19, 2023
Article in press: December 19, 2023
Published online: January 6, 2024
Processing time: 116 Days and 23.6 Hours
Core Tip

Core Tip: Glucose imbalance is common in total parenteral nutrition (TPN). Hypoglycemia seems to be less frequent than hyperglycemia, but it influences the clinical outcome to a greater extent. Therefore, it should be prevented and treated. At present, there is no relevant report on how to treat hypoglycemia caused by TPN in patients with liver cell injury. We reported that three patients with liver cell injury developed severe hypoglycemia during or after TPN. The causes of severe hypoglycemia and the strategy of increasing glucose were discussed, which can provide a reference for reducing the adverse consequences of hypoglycemia.