Karthikeyan S, Shen J, Keyashian K, Gubatan J. Small bowel adenocarcinoma in neoterminal ileum in setting of stricturing Crohn’s disease: A case report and review of literature . World J Clin Cases 2023; 11(9): 2021-2028 [PMID: 36998944 DOI: 10.12998/wjcc.v11.i9.2021]
Corresponding Author of This Article
John Gubatan, MD, Doctor, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Alway M211 MC 5187, Stanford, CA 94306, United States. jgubatan@stanford.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Mar 26, 2023; 11(9): 2021-2028 Published online Mar 26, 2023. doi: 10.12998/wjcc.v11.i9.2021
Small bowel adenocarcinoma in neoterminal ileum in setting of stricturing Crohn’s disease: A case report and review of literature
Shruthi Karthikeyan, Jeanne Shen, Kian Keyashian, John Gubatan
Shruthi Karthikeyan, Kian Keyashian, John Gubatan, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94306, United States
Jeanne Shen, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94306, United States
Author contributions: Karthikeyan S reviewed the literature, prepared case report, and wrote the manuscript; Shen J provided the gastrointestinal pathology interpretation and images and feedback regarding the manuscript; Keyashian K and Gubatan J provided critical feedback and drafted the manuscript.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: John Gubatan, MD, Doctor, Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 300 Pasteur Drive, Alway M211 MC 5187, Stanford, CA 94306, United States. jgubatan@stanford.edu
Received: November 14, 2022 Peer-review started: November 14, 2022 First decision: January 12, 2023 Revised: January 25, 2023 Accepted: March 3, 2023 Article in press: March 3, 2023 Published online: March 26, 2023 Processing time: 123 Days and 4.9 Hours
Core Tip
Core Tip: The prognosis of Crohn’s disease-induced small bowel adenocarcinomas (SBA) depends largely on staging at diagnosis, with early detection resulting in potentially improved outcomes. A multidisciplinary approach with gastroenterology, colorectal surgery, and radiology is key to this early diagnosis. Initially, a thorough family history can aid in decision-making with earlier intervention in those with stricturing phenotype and suggestion of higher colorectal cancer risk or syndrome. If imaging shows atypical features such as a mass, retrograde balloon enteroscopy should not be delayed. Finally, when surgical resection is considered in strictures refractory to medical therapy, lymph node sampling can aid in surgical staging of the SBA.
