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World J Clin Cases. Mar 16, 2023; 11(8): 1712-1718
Published online Mar 16, 2023. doi: 10.12998/wjcc.v11.i8.1712
Corneal endothelial cells and acoustic cavitation in phacoemulsification
Kai Chen, Wen-Ya Xu, Si-Si Sun, Hong-Wei Zhou
Kai Chen, Wen-Ya Xu, Si-Si Sun, Department of Ophthalmology, Lianshui County People's Hospital, Huai’an 223400, Jiangsu Province, China
Hong-Wei Zhou, Department of Ophthalmology, Huai’an 82 Hospital, Huai'an 223001, Jiangsu Province, China
Hong-Wei Zhou, Department of Industrial Engineering, Tsinghua University, Beijing 100084, China
Author contributions: Chen K and Xu WY searched the references, designed and discussed the manuscript; Zhou HW and Sun SS searched the references, designed, composed, revised and submitted the manuscript.
Conflict-of-interest statement: Chen K has received research funding from Scientific Research Project of Lianshui County Health Committee in 2022; Xu WY, Sun SS, and Zhou HW have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Zhou, MD, PhD, Chief Physician, Director, Doctor, Department of Ophthalmology, Huai’an 82 Hospital, No. 100 Jiankang Road, Qingjiang District, Huai'an 223001, Jiangsu Province, China. leave0307@163.com
Received: December 14, 2022
Peer-review started: December 14, 2022
First decision: January 3, 2023
Revised: January 14, 2023
Accepted: February 22, 2023
Article in press: February 22, 2023
Published online: March 16, 2023
Core Tip

Core Tip: Ultrasound in aqueous solution induces cavitation and promotes the formation of hydroxyl radicals or reactive oxygen species (ROS). ROS-induced apoptosis and autophagy in phacoemulsification have been suggested to significantly promote corneal endothelial cell (CEC) injury. Antioxidants can reduce the oxidative stress-induced injury to CECs during phacoemulsification.