Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2023; 11(6): 1349-1355
Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1349
Clinical manifestations of adult hereditary spherocytosis with novel SPTB gene mutations and hyperjaundice: A case report
Ni Jiang, Wu-Yong Mao, Bing-Xue Peng, Ting-Ya Yang, Xiao-Rong Mao
Ni Jiang, Wu-Yong Mao, Bing-Xue Peng, Ting-Ya Yang, Xiao-Rong Mao, Department of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Author contributions: Jiang N conducted data curation and wrote the manuscript; Mao WY revised and approved the final manuscript; and all authors contributed to the article and approved the submitted version.
Supported by Natural Science Foundation of Gansu Province, No. 21JR1RA070; and Construction of Clinical Medical Research Center, No. 21JR7RA392.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Rong Mao, MD, Chief Physician, Department of Infectious Diseases, The First Hospital of Lanzhou University, No. 1 Donggang West Road, Chengguan District, Lanzhou 730000, Gansu Province, China. mxr2013@126.com
Received: October 5, 2022
Peer-review started: October 5, 2022
First decision: November 22, 2022
Revised: December 17, 2022
Accepted: January 10, 2023
Article in press: January 10, 2023
Published online: February 26, 2023
Processing time: 142 Days and 6.7 Hours
Core Tip

Core Tip: A novel mutation in the SPTB gene was identified in a patient with hemolytic anemia, which caused the patient to present with extremely high jaundice without obvious hemolysis. At the same time, there was no similar mutation in the patient’s family. Because medical treatment was ineffective, we finally performed splenectomy after communicating with the patient. After splenectomy, the patient’s liver function recovered. The patient’s liver function continued to be normal during follow-up.