Opinion Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 26, 2023; 11(6): 1224-1235
Published online Feb 26, 2023. doi: 10.12998/wjcc.v11.i6.1224
Collagen matrix scaffolds: Future perspectives for the management of chronic liver diseases
Moises Martinez-Castillo, Itzel Altamirano-Mendoza, Rafal Zielinski, Waldemar Priebe, Cristina Piña-Barba, Gabriela Gutierrez-Reyes
Moises Martinez-Castillo, Itzel Altamirano-Mendoza, Gabriela Gutierrez-Reyes, Liver, Pancreas and Motility Laboratory, Unit of Experimental Medicine, School of Medicine, Universidad Nacional Autonoma de Mexico, Mexico City 06726, Mexico City, Mexico
Moises Martinez-Castillo, Rafal Zielinski, Waldemar Priebe, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, United States
Cristina Piña-Barba, Materials Research Institute, Universidad Nacional Autónoma de México, Mexico City 06726, Mexico City, Mexico
Author contributions: All the authors contributed in the writing and revision of manuscript; all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gabriela Gutierrez-Reyes, PhD, Academic Research, Professor, Research Scientist, Liver, Pancreas and Motility Laboratory, Unit of Experimental Medicine, School of Medicine, Universidad Nacional Autonoma de Mexico, Hospital General de Mexico, Dr Eduardo Liceaga, Dr. Balmis 148 Col Doctores Cuauhtemoc, Mexico City 06726, Mexico City, Mexico. gabgurey@yahoo.com.mx
Received: October 10, 2022
Peer-review started: October 10, 2022
First decision: October 28, 2022
Revised: November 28, 2022
Accepted: February 2, 2023
Article in press: February 2, 2023
Published online: February 26, 2023
Processing time: 136 Days and 15.6 Hours
Core Tip

Core Tip: The relevance of this review-opinion focuses on new strategies of regenerative medicine and the use of collagen matrix scaffolds as an option in the field of chronic liver disease (fibrosis/cirrhosis and hepatocellular carcinoma). Collagen matrix scaffold can be used as a niche for native or stem cells and as a carrier for antineoplastic drugs; these strategies exhibit the potential to restore liver function and address problems associated with the scarcity of organ donors.