Clinical Trials Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Feb 6, 2023; 11(4): 797-808
Published online Feb 6, 2023. doi: 10.12998/wjcc.v11.i4.797
Efficacy of incremental loads of cow’s milk as a treatment for lactose malabsorption in Japan
Matsuri Hasegawa, Kazuko Okada, Satoru Nagata, Shigetaka Sugihara
Matsuri Hasegawa, Shigetaka Sugihara, Department of Pediatrics, Tokyo Women’s Medical University Medical Center East, Arakawa-ku 116-8561, Tokyo, Japan
Kazuko Okada, Department of Pediatrics, Okada Pediatric Clinic, Shinjuku-ku 169-0072, Tokyo, Japan
Satoru Nagata, Department of Pediatrics, Tokyo Women’s Medical University, Shinjuku-ku 162-8666, Tokyo, Japan
Author contributions: Okada K and Nagata S conceptualized and designed the study outline; Hasegawa M and Okada K acquired, analyzed, and interpreted the data, as well as drafted the manuscript; Nagata S advised the interpretation of the data and the critical revision of the manuscript for important intellectual content; Sugihara S obtained funding and supervised the critical revision of the manuscript for important intellectual content; all authors have reviewed and approved the final manuscript.
Supported by Grants of J-milk (Japan Dairy Association).
Institutional review board statement: This work was approved by Tokyo Women’s Medical University Hospital Ethics Committee (approval number 160506).
Clinical trial registration statement: The trial described in this work was registered at https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026742 under trial number: UMIN 000023298.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors declare that they have no conflicts of interest for this article.
Data sharing statement: No additional date are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Matsuri Hasegawa, MD, Doctor, Department of Pediatrics, Tokyo Women’s Medical University Medical Center East, 2-1-10, Nishiogu, Arakawa-ku 116-8561, Tokyo, Japan. hasegawa.matsuri@twmu.ac.jp
Received: October 17, 2022
Peer-review started: October 17, 2022
First decision: November 11, 2022
Revised: December 2, 2022
Accepted: January 5, 2023
Article in press: January 5, 2023
Published online: February 6, 2023
Processing time: 112 Days and 3.5 Hours
Core Tip

Core Tip: The incidence of lactose malabsorption (LM) is high in East Asians such as Japan. Colonic adaptation by daily consumption of milk or lactose has been known as a method to treat LM, reducing symptoms of lactose intolerance (LI). However, reports regarding such treatment have not been found in Japan. In this study, we clarified the prevalence of LM diagnosed among the Japanese patients who had LI symptoms, and evaluated the efficacy of incremental loads of cow’s milk as a treatment for LM without affecting everyday life.