Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 6, 2023; 11(34): 8126-8138
Published online Dec 6, 2023. doi: 10.12998/wjcc.v11.i34.8126
Case-control analysis of venous thromboembolism risk in non-alcoholic steatohepatitis diagnosed by transient elastography
Mithil Gowda Suresh, Maya Gogtay, Yuvaraj Singh, Lekha Yadukumar, Ajay Kumar Mishra, George M Abraham
Mithil Gowda Suresh, Department of Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States
Maya Gogtay, Department of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE 68198, United States
Yuvaraj Singh, Department of Gastroenterology and Hepatology, University of Massachusetts, Worcester, MA 01605, United States
Lekha Yadukumar, Internal Medicine, The Wright Center for Graduate Medical Education, Scranton, PA 18505, United States
Ajay Kumar Mishra, Division of Cardiology, Saint Vincent Hospital, Worcester, MA 01608, United States
George M Abraham, Internal Medicine, Saint Vincent Hospital, Worcester, MA 01608, United States
Author contributions: Suresh MG conceived the idea for the study, designed and undertook the literature review, performed the statistical analysis, figures, and appendix and analyzed and interpreted the data; Suresh MG, Singh Y, and Gogtay M collected data; Suresh MG, Singh Y, Gogtay M, Gogtay M, and Yadukumar L wrote the first draft of the manuscript; Suresh MG, Gogtay M, Singh Y, Yadukumar L, Mishra AK, and Abraham GM revised the subsequent manuscript drafts; and all authors reviewed and agreed on the final draft of the manuscript.
Institutional review board statement: The comprehensive investigation into the potential link between non-alcoholic steatohepatitis and venous thromboembolism was conducted in adherence to a well-defined protocol. This protocol was developed, reviewed, and sanctioned by the joint institutional review board at MetroWest Medical Center under Approval No. 2020-035.
Informed consent statement: The ethical requirement for individual informed consent was appropriately waived by the institutional review board due to the retrospective nature of this case-control study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at mithil58@gmail.com. Consent was not obtained, but the presented data are anonymized, and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mithil Gowda Suresh, MD, Academic Fellow, Department of Internal Medicine, Saint Vincent Hospital, 123 Summer Street, Worcester, MA 01608, United States. mithilgowda1.suresh@stvincenthospital.com
Received: October 30, 2023
Peer-review started: October 30, 2023
First decision: November 1, 2023
Revised: November 6, 2023
Accepted: November 24, 2023
Article in press: November 24, 2023
Published online: December 6, 2023
Core Tip

Core Tip: Our study delineates the intricate relationship between nonalcoholic fatty liver disease (NAFLD) and venous thromboembolism (VTE), highlighting the increased risk and prevalence of VTE in patients with NAFLD-related conditions. Notably, it demonstrates a significant correlation between advanced steatosis and fibrosis grades and the occurrence of VTE, suggesting that patients with more severe NAFLD characteristics require vigilant monitoring for potential thrombotic complications. These insights delineate the necessity for tailored clinical approaches in managing NAFLD patients to mitigate the risk of VTE, marking a substantial step forward in understanding NAFLD’s systemic impacts.