Zhou QM, Zheng L. Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease. World J Clin Cases 2023; 11(34): 8111-8125 [PMID: 38130785 DOI: 10.12998/wjcc.v11.i34.8111]
Corresponding Author of This Article
Lie Zheng, PhD, Researcher, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 2 Xihuamen, Lianhu District, Xi’an 710003, Shaanxi Province, China. liezhenglielie@126.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Dec 6, 2023; 11(34): 8111-8125 Published online Dec 6, 2023. doi: 10.12998/wjcc.v11.i34.8111
Research progress on the relationship between Paneth cells-susceptibility genes, intestinal microecology and inflammatory bowel disease
Qi-Ming Zhou, Lie Zheng
Qi-Ming Zhou, Department of Nephrology, Lanxi Hospital of Traditional Chinese Medicine, Lanxi 321100, Zhejiang Province, China
Lie Zheng, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, Xi’an 710003, Shaanxi Province, China
Author contributions: Zhou QM and Zheng L contributed equally to this work, and both contributed to literature search, drafting of the manuscript, and providing approval of the final version to be published; Zhou QM and Zheng L contributed to the conception and design of the study and performed to the writing of the manuscript.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lie Zheng, PhD, Researcher, Department of Gastroenterology, Shaanxi Hospital of Traditional Chinese Medicine, No. 2 Xihuamen, Lianhu District, Xi’an 710003, Shaanxi Province, China. liezhenglielie@126.com
Received: July 27, 2023 Peer-review started: July 27, 2023 First decision: September 5, 2023 Revised: September 26, 2023 Accepted: November 27, 2023 Article in press: November 27, 2023 Published online: December 6, 2023 Processing time: 131 Days and 21.1 Hours
Core Tip
Core Tip: Inflammatory bowel disease (IBD) is a disorder of the immune system and intestinal microecosystem caused by environmental factors in genetically susceptible people. Paneth cells (PCs) play a central role in IBD pathogenesis, especially in Crohn's disease development, and their morphology, number and function are regulated by susceptibility genes. In the intestine, PCs participate in the formation of the stem cell microenvironment by secreting antibacterial particles and play a role in helping maintain the intestinal microecology and intestinal mucosal homeostasis. Moreover, PC proliferation and maturation depend on symbiotic flora in the intestine. This paper describes the interactions among susceptibility genes, PCs and intestinal microecology and their effects on IBD occurrence and development.
