Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2023; 11(31): 7647-7655
Published online Nov 6, 2023. doi: 10.12998/wjcc.v11.i31.7647
Intermittent spontaneous ovulation in patients with premature ovarian failure: Three case reports and review of literature
Wan-Yu Zhang, Han-Bi Wang, Cheng-Yan Deng
Wan-Yu Zhang, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Han-Bi Wang, Cheng-Yan Deng, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing 100730, China
Author contributions: Zhang WY reviewed literature and drafted the manuscript; Wang HB obtained patient consent; Deng CY revised the manuscript.
Supported by National High Level Hospital Clinical Research Funding, No. 2022-PUMCH-B-080; and No. PUMCH-C-064.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cheng-Yan Deng, MD, Doctor, Professor, Teacher, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. chydmd@hotmail.com
Received: August 11, 2023
Peer-review started: August 11, 2023
First decision: September 26, 2023
Revised: October 15, 2023
Accepted: October 25, 2023
Article in press: October 25, 2023
Published online: November 6, 2023
Processing time: 87 Days and 3.4 Hours
Core Tip

Core Tip: Three cases (29, 22, and 33 years of age) diagnosed with premature ovarian failure after experiencing secondary amenorrhea for more than one year, serum follicle-stimulating hormone levels > 40 IU/L. During the discontinuation period of artificial cycle, three patients experienced unpredictable and intermittent spontaneous follicle development, ovulation, and even natural pregnancy.