Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2023; 11(30): 7463-7468
Published online Oct 26, 2023. doi: 10.12998/wjcc.v11.i30.7463
Acute-on-chronic liver failure induced by antiviral therapy for chronic hepatitis C: A case report
Jiang-Li Zhong, Ling-Wei Zhao, Ying-Hua Chen, Ya-Wen Luo
Jiang-Li Zhong, Ying-Hua Chen, Ya-Wen Luo, Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Ling-Wei Zhao, Department of Hematology, The Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
Author contributions: Zhong JL contributed to manuscript writing and editing, and data collection; Zhao LW contributed to data analysis; Chen YH and Luo YW contributed to supervision; all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82160558; and Zunyi Science and Technology Fund.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Wen Luo, PhD, Chief Doctor, Department of Infectious Diseases, The Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi 563000, Guizhou Province, China. luoyw719@163.com
Received: July 31, 2023
Peer-review started: July 31, 2023
First decision: August 17, 2023
Revised: August 30, 2023
Accepted: September 26, 2023
Article in press: September 26, 2023
Published online: October 26, 2023
Processing time: 85 Days and 16.4 Hours
Core Tip

Core Tip: The advent of direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) has improved the rate of sustained virology response, resulting in clinical cure of CHC. We report a rare case of CHC where the patient developed acute-on-chronic liver failure during DAA therapy. Based on comprehensive analysis, the genotype of hepatitis C virus in this patient was unclear, and he was in an autoimmune hyperimmune state at the time and was coinfected with bacteria. When CHC is combined with the above conditions, close monitoring should be carried out during treatment to avoid a poor prognosis.