Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2023; 11(30): 7372-7379
Published online Oct 26, 2023. doi: 10.12998/wjcc.v11.i30.7372
Fatal hemophagocytic lymphohistiocytosis-induced multiorgan dysfunction secondary to Burkholderia pseudomallei sepsis: A case report
Ming-Ze Sui, Ke-Cheng Wan, Yuan-Lu Chen, Huan-Long Li, Shan-Shan Wang, Ze-Fu Chen
Ming-Ze Sui, Department of Pulmonary and Critical Care Medicine, Kunming Children’s Hospital, Yunnan Key Laboratory of Children’s Major Disease Research, Kunming 650034, Yunnan Province, China
Ke-Cheng Wan, Yuan-Lu Chen, Huan-Long Li, Shan-Shan Wang, Ze-Fu Chen, Department of Pediatrics, Hainan General Hospital, Haikou 570311, Hainan Province, China
Author contributions: Sui MZ and Wan KC contributed equally to this work; Sui MZ wrote the original draft of the manuscript; Wan KC performed the analysis and interpretation of imaging findings; Chen YL and Li HL were responsible for the treatment of the patient and provided clinical data; Wang SS was responsible for literature retrieval; Chen ZF was responsible for the revision and editing of the manuscript; All authors approved the final version to be submitted.
Informed consent statement: The patient’s parents signed a written informed consent form.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
CARE Checklist (2016) statement: The authors read the CARE Checklist (2016) and the manuscript was prepared and revised according to it Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ze-Fu Chen, BMed, Attending Doctor, Department of Pediatrics, Hainan General Hospital, Xiuhua Road, Haikou 570311, Hainan Province, China. 42648804@hainmc.edu.cn
Received: September 4, 2023
Peer-review started: September 4, 2023
First decision: September 13, 2023
Revised: September 24, 2023
Accepted: October 8, 2023
Article in press: October 8, 2023
Published online: October 26, 2023
Processing time: 51 Days and 7.4 Hours
Core Tip

Core Tip: Given the high mortality rate associated with Burkholderia pseudomallei (B. pseudomallei), it is particularly important to fully understand the pathogenesis. This report presents the clinical characteristics of a case of B. pseudomallei infection and some clinical data of the patient’s brother, who also died from B. pseudomallei infection. The chronic carrier status of B. pseudomallei and secondary hemophagocytic lymphohistiocytosis warrants attention in research on the pathogenesis and treatment of B. pseudomallei sepsis.