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World J Clin Cases. Jan 26, 2023; 11(3): 487-492
Published online Jan 26, 2023. doi: 10.12998/wjcc.v11.i3.487
Protective effects of combined treatment with ciprofol and mild therapeutic hypothermia during cerebral ischemia-reperfusion injury
Yi-Chao Wang, Meng-Jun Wu, Sheng-Liang Zhou, Zhi-Hui Li
Yi-Chao Wang, Sheng-Liang Zhou, Zhi-Hui Li, Department of Thyroid & Parathyroid Surgery Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Yi-Chao Wang, Sheng-Liang Zhou, Zhi-Hui Li, Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Meng-Jun Wu, Department of Anesthesiology, Chengdu Women and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology, Chengdu 610041, Sichuan Province, China
Author contributions: Wang YC designed the study, conducted the data collection, and drafted the manuscript; Wu MJ performed the data collection and helped in the manuscript preparation and data analysis; Zhou SL helped in the manuscript preparation, grammatical revision, and data analysis; Li ZH performed the statistical analysis and helped in the data collection and in the manuscript preparation; All the authors approved the final version of the paper and agree to be accountable for all aspects of the work thereby ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Conflict-of-interest statement: We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitled “Protective effects of combined treatment with Ciprofol and mild therapeutic hypothermia during cerebral ischemia-reperfusion injury”.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Hui Li, MD, Doctor, Department of Thyroid & Parathyroid Surgery Center, West China Hospital, Sichuan University; Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University. No. 37 Guoxue Lane, Wuhou District, Chengdu 640041, Sichuan Province, China. zhihuiliwt@163.com
Received: May 6, 2022
Peer-review started: May 6, 2022
First decision: June 9, 2022
Revised: June 13, 2022
Accepted: January 5, 2022
Article in press: January 5, 2023
Published online: January 26, 2023
Processing time: 265 Days and 8.5 Hours
Core Tip

Core Tip: Ciprofol (HSK3486) is a novel anesthetic agent that is convenient and easy to administer intravenously outside the operating room. Ciprofol is rapidly metabolized and accumulates at low concentrations after continuous infusion in a stable circulatory system compared to propofol. We hypothesize that HSK3486 can improve survival rates and achieve good neurological outcomes in cardiac arrest patients who receive therapeutic hypothermia.