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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 6, 2023; 11(28): 6715-6724
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6715
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6715
Effects of different doses of long-acting growth hormone in treating children with growth hormone deficiency
Wei Xia, Ting Wang, Department of Pediatrics, The First People's Hospital of Wuhu, Wuhu 241000, Anhui Province, China
Jia-Yan Pan, Department of Pediatric Endocrinology, The First People's Hospital of Wuhu, Wuhu 241000, Anhui Province, China
Author contributions: Pan JY contributed to the conceptualization, methodology, data analysis and software of the study, and supervised the study; Xia W contributed to validation of the study; Pan JY and Xia W analyzed the data; Ting Wang T contributed to resources; Xia W collected the data; Pan JY drafted the manuscript; Xia W reviewed and edited the manuscript.
Institutional review board statement: The study was approved by Institutional Review Board of Wuhu No. 1 People's hospital (Approval No. WHSDYRMYY-26).
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Yan Pan, MD, Attending Doctor, Department of Pediatric Endocrinology, The First People's Hospital of Wuhu, No. 1 Chizhu Shandong Road, Jiujiang District, Wuhu 241000, Anhui Province, China. jiayanpanvxv@163.com
Received: July 12, 2023
Peer-review started: July 12, 2023
First decision: August 2, 2023
Revised: August 3, 2023
Accepted: September 4, 2023
Article in press: September 4, 2023
Published online: October 6, 2023
Processing time: 75 Days and 7.4 Hours
Peer-review started: July 12, 2023
First decision: August 2, 2023
Revised: August 3, 2023
Accepted: September 4, 2023
Article in press: September 4, 2023
Published online: October 6, 2023
Processing time: 75 Days and 7.4 Hours
Core Tip
Core Tip: The lack of growth hormone deficiency (GHD) can lead to short stature in children, and our study explored the long-term efficacy and safety of different doses of long-acting polyethylene glycol recombinant human growth hormone (PEG-rhGH) in the treatment of GHD in children. Our study demonstrates that PEG-rhGH can be initiated at a low dosage, reducing the overall medical costs for patients and providing theoretical support for the clinical use of PEG-rhGH.