Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2023; 11(27): 6603-6612
Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6603
Recurrence of unilateral angioedema of the tongue: A case report
Yuki Matsuhisa, Tsuneaki Kenzaka, Hironori Shimizu, Hideo Hirose, Tadao Gotoh
Yuki Matsuhisa, Hironori Shimizu, Hideo Hirose, Tadao Gotoh, Department of General Medicine, Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori Hospital, Gujo 501-5122, Japan
Yuki Matsuhisa, Department of Pediatrics, Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori Hospital, Gujo 501-5122, Japan
Tsuneaki Kenzaka, Department of Internal Medicine, Hyogo Prefectural Tamba Medical Center, Tamba 669-3495, Japan
Tsuneaki Kenzaka, Division of Community Medicine and Career Development, Kobe University Graduate School of Medicine, Kobe 652-0032, Japan
Author contributions: Shimizu H, Hirose H, and Gotoh T contributed to data analysis; Matsuhisa Y contributed to investigation; Matsuhisa Y and Kenzaka T contributed to writing-original draft preparation; Matsuhisa Y, Kenzaka T; Shimizu H, Hirose H, and Gotoh T contributed to writing-review and editing; All authors have read and agreed to the published version of the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuki Matsuhisa, MD, Attending Doctor, Chief Doctor, Department of General Medicine, Center for Community Medicine in North-Western Gifu Prefecture National Health Insurance Shirotori Hospital, No. 1205-1 Tamezani, Shirotori-cho, Gujo 501-5122, Japan. m02084ym@jichi.ac.jp
Received: July 2, 2023
Peer-review started: July 2, 2023
First decision: August 16, 2023
Revised: August 24, 2023
Accepted: August 31, 2023
Article in press: August 31, 2023
Published online: September 26, 2023
Core Tip

Core Tip: This study describes the case of a 65-year-old woman who presented with unilateral angioedema of the tongue with no identifiable cause and who showed repeated recurrence of angioedema after discontinuation of an angiotensin-converting enzyme (ACE) inhibitor. She had a history of hypertension and hyperlipidemia for 32 years and had been receiving 20 mg/d of lisinopril for 32 years. The ACE inhibitor was suspected as the cause of angioedema; therefore, its use was discontinued. However, angioedema of the left unilateral tongue continued to recur. Recurrence of the unilateral angioedema did not occur following the administration of 500 mg of tranexamic acid.