Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2023; 11(27): 6407-6414
Published online Sep 26, 2023. doi: 10.12998/wjcc.v11.i27.6407
Correlation analysis of serum thyroglobulin, thyroid-stimulating hormone levels, and thyroid-cancer risk in thyroid nodule surgery
Jin-Hao Shuai, Zhao-Fang Leng, Peng Wang, Yi-Chi Ji
Jin-Hao Shuai, Zhao-Fang Leng, Peng Wang, Yi-Chi Ji, Department of Thyroid and Breast Surgery, Meishan City People's Hospital, Meishan 620000, Sichuan Province, China
Author contributions: Shuai JH contributed to conception, design, administrative support, manuscript writing, data analysis, and interpretation; Shuai JH and Leng ZF contributed to provision of study materials; All authors contributed to collection and assembly of data; All authors contributed to final approval of manuscript.
Institutional review board statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was approved by Institutional Review Board of Meishan City People's Hospital.
Informed consent statement: All study participants, or their legal guardian, provided written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin-Hao Shuai, MM, PhD, Doctor, Professor, Department of Thyroid and Breast Surgery, Meishan City People's Hospital, No. 288 South Section 4, Dongpo Avenue, Dongpo District, Meishan 620000, Sichuan Province, China. jinhaoshuai236@163.com
Received: August 1, 2023
Peer-review started: August 1, 2023
First decision: August 16, 2023
Revised: August 22, 2023
Accepted: August 29, 2023
Article in press: August 29, 2023
Published online: September 26, 2023
Processing time: 50 Days and 15.7 Hours
Core Tip

Core Tip: This study aimed to investigate the potential association of serum thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) levels with the risk of thyroid cancer among patients undergoing thyroid nodule surgery. Moreover, we retrospectively analyzed the clinical data and laboratory results of 130 patients who underwent thyroid nodule surgery. Their preoperative Tg and TSH levels were recorded, and subsequent histopathological examinations were conducted during follow-up to determine the presence of thyroid cancer. These results indicated that serum Tg levels were significantly correlated with the risk of thyroid cancer (P < 0.05), suggesting that high Tg levels are associated with an increased likelihood of developing thyroid cancer. However, no significant correlation was observed between serum TSH levels and thyroid cancer risk (P > 0.05). In conclusion, this study highlighted that in patients undergoing thyroid nodule surgery, serum Tg can serve as an important biomarker for assessing the risk of thyroid cancer, whereas serum TSH does not exhibit a significant predictive relationship.