Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2023; 11(26): 6289-6297
Published online Sep 16, 2023. doi: 10.12998/wjcc.v11.i26.6289
Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology: A case report and literature review
Meng Jiang, Xiao-Ping Yuan
Meng Jiang, School of Medicine, Sun Yat-sen University, Shenzhen 518107, Guangdong Province, China
Xiao-Ping Yuan, Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Author contributions: All the authors contributed to manuscript writing and editing, and data collection; Jiang M performed statistical analysis and drafted the manuscript; Yuan XP performed the literature review and revised the manuscript; All authors have read and approved the final manuscript.
Supported by National College Students Innovation and Entrepreneurship Training Program, No. 202110558154; College Students Innovation and Entrepreneurship Training Program of Sun Yat-sen University, No. 202211534; and No. 202311516.
Informed consent statement: Informed written consent was obtained from her family members to publish this case report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ping Yuan, MD, Director, Doctor, Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No. 107 Yanjiang West Road, Guangzhou 510120, Guangdong Province, China. yuanxp@mail.sysu.edu.cn
Received: June 17, 2023
Peer-review started: June 17, 2023
First decision: August 4, 2023
Revised: August 15, 2023
Accepted: August 21, 2023
Article in press: August 21, 2023
Published online: September 16, 2023
Processing time: 83 Days and 0.3 Hours
Core Tip

Core Tip: Coexisting of primary diffuse large B-cell lymphoma (DLBCL) and adenocarcinoma in the colon are extremely rare. Here, we report a case of collision tumor of primary DLBCL, not otherwise specified with germinal center B-cell subtype and TP53 mutation, and adenocarcinoma arising in a tubulovillous adenoma in the colon, with BRAF mutation and mutL homolog 1 promoter methylation. Definite diagnosis is usually difficult until pathological confirmation. Based on pathological examination and genetic analysis, surgery combined with dose-adjusted chemotherapy or chemoradiotherapy may have good therapeutic effects.