Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5666-5677
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5666
Hypopharyngeal cancer trends in a high-incidence region: A retrospective tertiary single center study
Alina-Georgiana Vulcu Cordunianu, Gabriel Ganea, Mihai Alexandru Cordunianu, Daniel Cochior, Cosmin Alec Moldovan, Razvan Adam
Alina-Georgiana Vulcu Cordunianu, Mihai Alexandru Cordunianu, Doctoral School of Medicine, Titu Maiorescu University of Bucharest, Bucharest 040317, Romania
Alina-Georgiana Vulcu Cordunianu, Gabriel Ganea, Department of Ear Nose Throat Head and Neck Surgery, Carol Davila Central University Emergency Military Hospital, Bucharest 10825, Romania
Mihai Alexandru Cordunianu, Department of Pediatric Orthopedics, Victor Gomoiu Hospital, Bucharest 022102, Romania
Daniel Cochior, Cosmin Alec Moldovan, Razvan Adam, Department of Medical-Surgical and Prophylactic Disciplines, Faculty of Medicine, Titu Maiorescu University, Bucharest 031593, Romania
Daniel Cochior, Department of General Surgery, Sanador Clinical Hospital, Bucharest 010991, Romania
Daniel Cochior, Department of General Surgery, Monza Clinical Hospital, Bucharest 021967, Romania
Cosmin Alec Moldovan, Department of General Surgery, Witting Clinical Hospital, Bucharest 010243, Romania
Razvan Adam, Department of Orthopedics and Traumatology, Elias Emergency University Hospital, Bucharest 011461, Romania
Author contributions: Cordunianu AGV and Cochior D made the design and concept of the present study; Ganea G and Cordunianu AGV aquired the patient data and cofirmed authenticity of all raw data; Moldovan CA and Adam R performed data analysis and literature review; Cordunianu AGV and Moldovan CA drafted the initial manuscript; Cochior D and Moldovan CA revised the final manuscript; Cochior D critically revised the manuscript for intellectual content; All authors have read and approved the final manuscript.
Institutional review board statement: This study was authorized by the Ethics Committee of Titu Maiorescu Doctoral School (Bucharest, Romania) number 15/2022 and by the Ethics Committee of Carol Davila Central University Emergency Military Hospital (Bucharest, Romania) number 538/2022.
Informed consent statement: All patients provided written informed consent for data usage and publication in research purposes.
Conflict-of-interest statement: The authors declare no conflict-of-interest.
Data sharing statement: The data used and analyzed in this study are available from the corresponding author on reasonable request at cosmin.moldovan@prof.utm.ro.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Cosmin Alec Moldovan, MD, PhD, Associate Professor, Department of Medical-Surgical and Prophylactic Disciplines, Faculty of Medicine, Titu Maiorescu University, Gheorghe Petrascu 67A Street, 3rd District, Bucharest 031593, Romania. cosmin.moldovan@prof.utm.ro
Received: April 2, 2023
Peer-review started: April 2, 2023
First decision: May 31, 2023
Revised: June 11, 2023
Accepted: July 31, 2023
Article in press: July 31, 2023
Published online: August 26, 2023
Processing time: 144 Days and 13.6 Hours
Core Tip

Core Tip: This retrospective study analyzed 53 hypopharyngeal cancer patients' data, focusing on diagnostic methods, treatment strategies, and quality-of-life assessments using Adult Comorbidity Evaluation-27, Karnofski Performance Status Scale, and European Organisation for Reasearch and Treatment of Cancer Quality of Life Questionnaire Head and Neck-35. Our findings discovered that most patients had advanced stage cancer, frequent smoking history, and comorbidities. Various treatments were applied, with mixed responses and a 30.18% follow-up rate. Late-stage diagnosis resulted in decreased capacity function; 83% had comorbidities. Organ conservation therapies were preferred by 43.39%, driven by similar survival rates and quality of life considerations. In conclusion, all the data we found was similar to the one found in literature, but with a higher degree of severity and a younger age at diagnosis compared to the most studies.