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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2023; 11(24): 5628-5642
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5628
Published online Aug 26, 2023. doi: 10.12998/wjcc.v11.i24.5628
Effect of pesticides on phosphorylation of tau protein, and its influence on Alzheimer’s disease
Erandis D Torres-Sánchez, Emmanuel Reyes-Uribe, Joel Salazar-Flores, Department of Medical and Life Sciences, University Center of la Cienega, University of Guadalajara, Ocotlan 47820, Jalisco, Mexico
Genaro G Ortiz, Department of Philosophical and Methodological Disciplines and Service of Molecular Biology in Medicine Hospital Civil, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico
Juan H Torres-Jasso, Department of Biological Sciences, CUCOSTA, University of Guada
Author contributions: Torres-Sánchez ED and Salazar-Flores J contributed to the conceptualization of this study; Torres-Sánchez ED, Ortiz GG, Reyes-Uribe E, Torres-Jasso JH, and Salazar-Flores J involved in the investigation of this manuscript; Reyes-Uribe E, Torres-Jasso JH, and Salazar-Flores J contributed to the writing-original draft preparation; Torres-Sánchez ED and Ortiz GG involved in the writing-review and editing; Torres-Sánchez ED, Ortiz GG and Reyes-Uribe E contributed to the figures; Salazar-Flores J contributed to the supervision of this article.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Joel Salazar-Flores, PhD, Department of Medical and Life Sciences, University Center of la Cienega, University of Guadalajara, Linda Vista 1115, Ocotlan 47820, Jalisco, Mexico. joel.salazar@academicos.udg.mx
Received: May 22, 2023
Peer-review started: May 22, 2023
First decision: July 3, 2023
Revised: July 17, 2023
Accepted: August 8, 2023
Article in press: August 8, 2023
Published online: August 26, 2023
Processing time: 95 Days and 7.6 Hours
Peer-review started: May 22, 2023
First decision: July 3, 2023
Revised: July 17, 2023
Accepted: August 8, 2023
Article in press: August 8, 2023
Published online: August 26, 2023
Processing time: 95 Days and 7.6 Hours
Core Tip
Core Tip: Exposure to pesticides occurs frequently through contact with contaminated particles, food, or water. In 2022, the Alzheimer’s Association emphasized that contact with these pollutants is a risk factor for Alzheimer diseases. This study showed that contact with organochlorines, organophosphates, carbamates, pyrethroids and neonicotinoids modified mechanisms related to tau hyperphosphorylation and neuroinflammation. In cognitive findings, these chemicals altered memory, attention, and problem-solving processes. Few published studies have evaluated the effect of these pesticides on tau protein. Therefore, this review is novel in the sense that it presents an analysis for each pesticide class.