Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2023; 11(23): 5416-5429
Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5416
Published online Aug 16, 2023. doi: 10.12998/wjcc.v11.i23.5416
Recent progress in understanding mitokines as diagnostic and therapeutic targets in hepatocellular carcinoma
Jiang Wang, Lan-Zhu Luo, Zhi-Hong Huang, Children Medical Center, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Dao-Miao Liang, Chao Guo, Department of Hepatobiliary Surgery, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Xiao-Hong Jian, Department of Anatomy, Hunan Normal University School of Medicine, Changsha 410013, Hunan Province, China
Jie Wen, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410013, Hunan Province, China
Author contributions: Wang J and Luo LZ contribute equally to this study, they share co-first author; Wang J wrote the paper; Luo LZ and Liang DM did the literature review; Guo C and Huang ZH did the data analysis; Jian XH conceived and coordinated the study; Wen J revised the paper; Jian XH and Wen J contribute equally to this study, they share co-correspondent author; all authors reviewed the results and approved the final version of the manuscript.
Supported by Scientific Research Project of Hunan Education Department , No. 21A0054 .
Conflict-of-interest statement: The authors declare that they have no competing interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie Wen, PhD, Associate Professor, Department of Pediatric Orthopedics, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, No. 61 West Jiefang Road, Changsha 410013, Hunan Province, China.
Received: May 18, 2023
Peer-review started: May 18, 2023
First decision: July 3, 2023
Revised: July 14, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: August 16, 2023
Processing time: 89 Days and 15.9 Hours
Peer-review started: May 18, 2023
First decision: July 3, 2023
Revised: July 14, 2023
Accepted: August 3, 2023
Article in press: August 3, 2023
Published online: August 16, 2023
Processing time: 89 Days and 15.9 Hours
Core Tip
Core Tip: The progression and metastasis of hepatocellular carcinoma (HCC) are intricately associated with alterations in mitochondrial metabolism. Mitokines, as critical cellular factors during mitochondrial stress, play an indispensable role in maintaining dynamic equilibrium within cells, intercellularly, and intertissue during mitochondrial stress. Through quantifying mitokine levels, we can assess the severity of HCC and predict the efficacy of treatment in HCC patients. The pursuit of highly specific and sensitive drugs targeting mitokines for HCC treatment represents a promising avenue for future research endeavors.