Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 6, 2023; 11(22): 5215-5223
Published online Aug 6, 2023. doi: 10.12998/wjcc.v11.i22.5215
Changes in neurotransmitter levels, brain structural characteristics, and their correlation with PANSS scores in patients with first-episode schizophrenia
Xian-Jia Xu, Tang-Long Liu, Liang He, Ben Pu
Xian-Jia Xu, The Fifth Ward, Ningbo Psychiatric Hospital, Ningbo 315000, Zhejiang Province, China
Tang-Long Liu, Department of Science and Education, Ningbo Psychiatric Hospital, Ningbo 315000, Zhejiang Province, China
Liang He, The Sixteenth Ward, Ningbo Psychiatric Hospital, Ningbo 315000, Zhejiang Province, China
Ben Pu, The Twelfth Ward, Ningbo Psychiatric Hospital, Ningbo 315000, Zhejiang Province, China
Author contributions: Xu XJ and Pu B designed the research study; Liu TL and He L performed the research; Xu XJ and Pu B analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Ningbo Mental Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ben Pu, B.S.Me, Doctor, The Twelfth Ward, Ningbo Psychiatric Hospital, No. 11 Rixingfang, Tongjia Village, Zhuangqiao Street, Jiangbei District, Ningbo 315000, Zhejiang Province, China. vickipu@126.com
Received: May 31, 2023
Peer-review started: May 31, 2023
First decision: June 14, 2023
Revised: June 15, 2023
Accepted: July 10, 2023
Article in press: July 10, 2023
Published online: August 6, 2023
Processing time: 64 Days and 7.8 Hours
Core Tip

Core Tip: In this study, the relationship between the changes of neurotransmitter and brain structure characteristics and Positive and Negative Symptom Scale (PANSS) score in patients with first episodes of schizophrenia was investigated. It was found that there were differences in the levels of dopamine, glutamic acid and gamma-aminobutyric acid in the brain of the study subjects, as well as the brain structure characteristics detected by magnetic resonance imaging between the two groups, and there is a certain correlation with PANSS score.