Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2023; 11(20): 4932-4936
Published online Jul 16, 2023. doi: 10.12998/wjcc.v11.i20.4932
Unexpected diffuse lung lesions in a patient with pulmonary alveolar proteinosis: A case report
Li Jian, Qi-Quan Zhao
Li Jian, Department of Endocrinology, Dazu Hospital of Chongqing Medical University, The People's Hospital of Dazu, Chongqing 402360, China
Qi-Quan Zhao, Department of Respiratory and Critical Care Medicine, Dazu Hospital of Chongqing Medical University, The People's Hospital of Dazu, Chongqing 402360, China
Author contributions: Jian L contributed to writing the manuscript and participated in helpful discussions; Zhao QQ is the guarantor of this work.
Supported by the Joint Project of Chongqing Health Commission and Science and Technology Bureau, No. 2022MSXM103.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest and agreed to publish the study.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi-Quan Zhao, MMed, Department of Respiratory and Critical Care Medicine, Dazu Hospital of Chongqing Medical University, The People's Hospital of Dazu, No. 1073 2nd Ring South Road, Tangxiang Street, Dazu District, Chongqing 402360, China. 316318057@qq.com
Received: March 20, 2023
Peer-review started: March 20, 2023
First decision: May 31, 2023
Revised: June 9, 2023
Accepted: June 26, 2023
Article in press: June 26, 2023
Published online: July 16, 2023
Processing time: 108 Days and 22.3 Hours
Core Tip

Core Tip: Pulmonary alveolar proteinosis (PAP) is frequently misdiagnosed due to the absence of typical map-like and pavement-like manifestations in the lungs or the absence of typical pathological findings. Transbronchial cryobiopsy has unique advantages in diagnosing atypical alveolar protein deposition, particularly for enabling the early detection of PAP. This information can help patients take preventive measures to prevent or halt PAP development by avoiding dusty environments and seeking treatment with total lung lavage and inhaled granulocyte macrophage colony-stimulating factor.