Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 16, 2023; 11(20): 4912-4919
Published online Jul 16, 2023. doi: 10.12998/wjcc.v11.i20.4912
Metagenomic next-generation sequencing in the diagnosis of neurocysticercosis: A case report
Wen-Bin Xu, Juan-Juan Fu, Xiao-Ju Yuan, Qing-Jie Xian, Li-Jun Zhang, Ping-Ping Song, Zhi-Qing You, Cheng-Tan Wang, Qi-Gang Zhao, Feng Pang
Wen-Bin Xu, Juan-Juan Fu, Qing-Jie Xian, Ping-Ping Song, Zhi-Qing You, Cheng-Tan Wang, Qi-Gang Zhao, Feng Pang, Department of Clinical Laboratory, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Xiao-Ju Yuan, Department of Gastroenterology, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Li-Jun Zhang, Department of Neurology, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Author contributions: Xu WB, Fu JJ and Yuan XJ contributed equally to this work. Xu WB, Fu JJ, and Yuan XJ carried out the studies, performed the statistical analysis, and drafted the manuscript; Xu WB, Fu JJ, Xian QJ, and Yuan XJ revised the manuscript; Zhang LJ collected the clinical data and analyzed the data; Song PP, You ZQ, and Wang CT contributed in metagenomic next-generation sequencing experiment and result analysis; Pang F and Zhao QG contributed conception and design of the study; and all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Check list (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Pang, MD, PhD, Professor, Department of Clinical Laboratory, Liaocheng People’s Hospital, No. 67 Dongchang Road, Liaocheng 252000, Shandong Province, China. pangfeng01@163.com
Received: March 12, 2023
Peer-review started: March 12, 2023
First decision: May 8, 2023
Revised: May 21, 2023
Accepted: June 26, 2023
Article in press: June 26, 2023
Published online: July 16, 2023
Processing time: 122 Days and 2.7 Hours
Core Tip

Core Tip: Neurocysticercosis (NCC) infection is rare, and the diagnostic methods are limited. Here we report a case of Taenia solium infection that was diagnosed by metagenomic next-generation sequencing (mNGS) using cerebrospinal fluid samples. Finally, after anti-parasite treatment, the headaches disappeared and the patient recovered well, and various indicators gradually returned to normal during the follow-up period. This indicates that mNGS can be a reliable approach for the diagnosis of NCC, due to its accuracy and sensitivity.