Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2023; 11(19): 4640-4647
Published online Jul 6, 2023. doi: 10.12998/wjcc.v11.i19.4640
CK5/6-positive, P63-positive lymphoepithelioma-like hepatocellular carcinoma: A case report and literature review
Hong-Tao Tang, Wei Lin, Wei-Qiao Zhang, Jun-Lin Qian, Kai Li, Kun He
Hong-Tao Tang, Wei Lin, Wei-Qiao Zhang, Jun-Lin Qian, Kai Li, Graduate School of Guangdong Medical University, Zhanjiang 524002, Guangdong Province, China
Hong-Tao Tang, Kun He, Department of Hepatobiliary Surgery, Zhongshan People’s Hospital, Zhongshan 528400, Guangdong Province, China
Author contributions: Tang HT analysed the relevant literature and wrote the manuscript; He K led the whole process, including the operation, and directed the writing of the manuscript; Lin W and Zhang WQ participated in the data collection; Qian JL was in charge of the long-term follow-up of the patient.
Supported by Zhongshan Bureau of Science and Technology, No. 2017B1044; and No. 2017SYF04.
Informed consent statement: Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report that they have no conflicts of interest related to this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kun He, MD, PhD, Director, Doctor, Professor, Chief Physician, Department of Hepatobiliary Surgery, Zhongshan People’s Hospital, No. 2 Sunwen East Road, Shiqi District, Zhongshan 528400, Guangdong Province, China. hekun80@126.com
Received: January 15, 2023
Peer-review started: January 15, 2023
First decision: February 1, 2023
Revised: February 11, 2023
Accepted: June 9, 2023
Article in press: June 9, 2023
Published online: July 6, 2023
Processing time: 166 Days and 7 Hours
Core Tip

Core Tip: Primary hepatocellular lymphoepithelioma-like carcinoma (LELC) is a rare disease. We review the relevant literature, and only a few clinical cases have been reported worldwide. The patient in this case report was eventually diagnosed with primary hepatocellular LELC based on her family history, magnetic resonance imaging scans, and immunohistochemical findings. Herein, we summarize and discuss this case and review the pathogenesis, clinical manifestations, diagnosis, and treatment of primary hepatocellular LELC.