Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 6, 2023; 11(19): 4553-4566
Published online Jul 6, 2023. doi: 10.12998/wjcc.v11.i19.4553
Network pharmacology and molecular docking-based analyses to predict the potential mechanism of Huangqin decoction in treating colorectal cancer
Ying-Jie Li, Dong-Xin Tang, Hong-Ting Yan, Bing Yang, Zhu Yang, Feng-Xi Long
Ying-Jie Li, Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550005, Guizhou Province, China
Dong-Xin Tang, Bing Yang, Digestive Department, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, Guizhou Province, China
Hong-Ting Yan, Zhu Yang, Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang 550001, Guizhou Province, China
Feng-Xi Long, Guizhou University of Traditional Chinese Medicine, Guizhou University of Traditional Chinese Medicine, Gui Yang 550001, Guizhou Province, China
Author contributions: Li YJ and Tang DX contributed equally to this work; Yan HT designed the study; Yang B contributed to the analysis of the manuscript; Yang Z and Long FX were involved in the data acquisition and writing of this article; All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 82260957; No. 82274610; No. 81860819; No. 81860819; and No. 81960818; Guizhou Provincial Science and Technology Program (Qian Kehe Foundation-ZK[2022] General 498, Qian Kehe Foundation-ZK [2022] General 487, Qian Kehe Support [2021] General 095, Qian Kehe Platform Talent [2020]5013); National Key R&D Program Project (2019YFC1712504); Guizhou Traditional Chinese Medicine Tumor Inheritance and Science and Technology Innovation Talent Base (No. Deaf leader-[2018] No. 3); Guizhou high-level innovative talent training plan (100 levels) (No. Qian Kehe Talents [2016] No. 4032); Yang Zhu, Guizhou Province, “Traditional Chinese Medicine Oncology” Graduate Tutor Studio (No. Teaching and research GZS-[2016]08).
Institutional review board statement: The study was reviewed and approved by the Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China, Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Xin Tang, MD, Doctor, Digestive Department, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, No. 71 Baoshan North Road, Nanming District, Guiyang 550001, Guizhou Province, China. tangdongxin@sina.com
Received: April 24, 2023
Peer-review started: April 24, 2023
First decision: May 8, 2023
Revised: May 27, 2023
Accepted: June 13, 2023
Article in press: June 13, 2023
Published online: July 6, 2023
Processing time: 67 Days and 4.8 Hours
Core Tip

Core Tip: Huangqin decoction may treat colorectal cancer through multi-component targeting and modulation of multiple signaling pathways.