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World J Clin Cases. Jun 26, 2023; 11(18): 4251-4257
Published online Jun 26, 2023. doi: 10.12998/wjcc.v11.i18.4251
Bicuspid aortic valve with associated aortopathy, significant left ventricular hypertrophy or concomitant hypertrophic cardiomyopathy: A diagnostic and therapeutic challenge
Ivana Sopek Merkaš, Nenad Lakušić, Mladen Predrijevac, Krešimir Štambuk, Maja Hrabak Paar
Ivana Sopek Merkaš, Nenad Lakušić, Department of Cardiology, Special Hospital for Medical Rehabilitation Krapinske Toplice, Krapinske Toplice 49217, Croatia
Nenad Lakušić, Krešimir Štambuk, Department of Clinical Medicine, Faculty of Dental Medicine and Health Osijek, J. J. Strossmayer University of Osijek, Osijek 31000, Croatia
Nenad Lakušić, Department of Internal Medicine, Family Medicine and History of Medicine, Faculty of Medicine Osijek, J. J. Strossmayer University of Osijek, Osijek 31000, Croatia
Mladen Predrijevac, Department of Cardiovascular Surgery, Magdalena Clinic for Cardiovascular Diseases, Krapinske Toplice 49217, Croatia
Krešimir Štambuk, Department of Cardiology, Magdalena Clinic for Cardiovascular Diseases, Krapinske Toplice 49217, Croatia
Maja Hrabak Paar, Department of Diagnostic and Interventional Radiology, University Hospital Centre Zagreb, Zagreb 10000, Croatia
Maja Hrabak Paar, School of Medicine, University of Zagreb, Zagreb 10000, Croatia
Author contributions: Sopek Merkaš I and Lakušić N were responsible for the conception and design of the manuscript, literature review, data collection and processing, and they wrote the first original draft; Predrijevac M and Štambuk K, contributed in data collection, literature review and design; Lakušić N, Štambuk K, Predrijevac M contributed in making critical revisions related to the important intellectual content of the manuscript; Hrabak Paar M analyzed and interpreted the CT and MR imaging findings, literature review, and making critical revisions related to the important intellectual content; all authors issued final approval for the version to be submitted.
Conflict-of-interest statement: We have no conflict-of-interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ivana Sopek Merkaš, MD, Doctor, Department of Cardiology, Special Hospital for Medical Rehabilitation Krapinske Toplice, Gajeva 2, Krapinske Toplice 49217, Croatia. ivana.sopek@sbkt.hr
Received: March 26, 2023
Peer-review started: March 26, 2023
First decision: May 12, 2023
Revised: May 19, 2023
Accepted: May 24, 2023
Article in press: May 24, 2023
Published online: June 26, 2023
Core Tip

Core Tip: Bicuspid aortic valve accompanied by significant left ventricular hypertrophy, with echocardiographic parameters suggesting possible obstruction of the left ventricular output tract, requires additional diagnostic workup to exclude obstruction other than at the aortic valve level, as well as possible associated hypertrophic cardiomyopathy. A multidisciplinary approach in the heart team and the utilization of multimodal imaging are imperative for the accurate diagnosis and appropriate management of such patients.