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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2023; 11(17): 4105-4116
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.4105
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.4105
Flared inflammatory episode transforms advanced myelodysplastic syndrome into aplastic pancytopenia: A case report and literature review
Bo Ju, Nuan-Nuan Xiu, Jia Xu, Xiao-Dong Yang, Xiao-Yun Sun, Xi-Chen Zhao, Department of Hematology, The Central Hospital of Qingdao West Coast New Area, Qingdao 266555, Shandong Province, China
Author contributions: Zhao XC developed the idea; Ju B and Xiu NN analyzed the data and drafted the manuscript; Ju B, Xiu NN, Xu J, and Yang XD participated in the treatment; Sun XY supervised the treatment; Zhao XC revised the final manuscript; All authors have read and approved the final version of the manuscript.
Supported by The Specialized Scientific Research Fund Projects of The Medical Group of Qingdao University , No. YLJT20201002 .
Informed consent statement: Informed written consent was obtained from the patient to publish this case report and any accompanying laboratory data.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read CARE Checklist (2016), and the manuscript was prepared and revised according to CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xi-Chen Zhao, MD, Chief Physician, Department of Hematology, The Central Hospital of Qingdao West Coast New Area, No. 9 Huangpujiang Road, Qingdao 266555, Shandong Province, China. zhaoxc7150@163.com
Received: March 10, 2023
Peer-review started: March 10, 2023
First decision: April 10, 2023
Revised: April 21, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: June 16, 2023
Peer-review started: March 10, 2023
First decision: April 10, 2023
Revised: April 21, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: June 16, 2023
Core Tip
Core Tip: In patients with myelodysplastic syndrome, bone marrow cellularity and the percentage of myeloblasts generally increase with disease progression. Transformation from advanced myelodysplastic syndrome to aplastic cytopenia with leukemic cell regression has not previously been reported. Here, we report a case of this disease phenotypic transformation. The cause for the disease transformation was a disseminated inflammatory condition involving the lungs, mediastinum, pleura, gastrointestinal tract, peritoneum and urinary tract. This case study demonstrated that in myeloid neoplasms, disseminated inflammatory conditions can suppress both normal and leukemic hematopoiesis.