Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2023; 11(17): 4060-4064
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.4060
Pregabalin induced balance disorder, asthenia, edema, and constipation in an elderly adult: A case report
Li-Ping Ma, Cheng Wen, Tong-Xiang Zhao, Xiang-Ming Jiang, Jin Gu
Li-Ping Ma, Tong-Xiang Zhao, Xiang-Ming Jiang, Office of Clinical Trial Institution, Peking University Shougang Hospital, Beijing 100144, China
Cheng Wen, Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
Jin Gu, Department of Gastrointestinal Surgery, Peking University Shougang Hospital, Beijing 100144, China
Author contributions: Ma LP and Wen C contributed to manuscript writing and editing; Ma LP contributed to data collection; Zhao TX and Jiang XM contributed to data audit; Gu J contributed to conceptualization and supervision; All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin Gu, PhD, Dean, Doctor, Professor, Surgeon, Department of Gastrointestinal Surgery, Peking University Shougang Hospital, No. 10 Jinyuan Road, Shijingshan District, Beijing 100144, China. applemary18@163.com
Received: December 7, 2022
Peer-review started: December 7, 2022
First decision: January 17, 2023
Revised: February 3, 2023
Accepted: March 31, 2023
Article in press: March 31, 2023
Published online: June 16, 2023
Processing time: 180 Days and 16.5 Hours
Core Tip

Core Tip: This is the first report regarding dose-related adverse drug reactions (ADRs) of balance disorder, asthenia, peripheral edema, and constipation simultaneously in an elderly patient after treatment with pregabalin, which suggests that older patients whose creatinine clearance < 60 mL/min should be prescribed a lower initial dose. Titration to the highest tolerable dose should be done cautiously to avoid dose-limiting ADRs. Dose reduction and the addition of acetaminophen for pregabalin may be useful for limiting ADRs and improving patient pain control.