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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2023; 11(17): 4019-4025
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.4019
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.4019
Elastic fiber degradation in the development of pediatric granuloma annulare: Report of 39 cases
Dong-Yuan Zhang, Li Zhang, Hong Shu, Department of Dermatology, Kunming Children’s Hospital, Kunming 650000, Yunnan Province, China
Qin-Yan Yang, Department of Human Resource, Kunming Children’s Hospital, Kunming 650000, Yunnan Province, China
Yu-Cheng Xie, Department of Pathology, Kunming Children’s Hospital, Kunming 650000, Yunnan Province, China
Hong-Chao Jiang, Institute of Pediatric Disease Research in Yunnan, Kunming Children’s Hospital, Kunming 650000, Yunnan Province, China
Jia-Zheng Li, Department of Emergency, The Cooperation of Chinese and Western Medicine Hospital of Yunnan Province, Kunming 650000, Yunnan Province, China
Author contributions: Zhang DY and Zhang L substantial contribution to the conception and design of the work; Zhang DY, Zhang L, Xie YC, Li JZ, and Yang QY contribution to the acquisition, analysis, interpretation of data for the work; Zhang DY contributions to article writing and revising; Jiang HC and Shu H contribution to critical manuscript revisions for project design; Yang QY agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved; Shu H contributions to final approval of the version to be published; All authors have read and approve the final manuscript; Zhang DY and Zhang L contributed equally to this work; They are substantial contribution to the conception and design of the work.
Supported by Spring City Project Famous Doctor Special.
Institutional review board statement: The study protocol was reviewed and approved by Kunming Children’s Hospital Medicine Ethics Committee, approval number 2022-03-325-K01.
Informed consent statement: Kunming Children’s Hospital Medicine Ethics Committee concluded that this study was ethical and determined that written informed consent was not required.
Conflict-of-interest statement: All the authors have no conflicts of interest to declare.
Data sharing statement: The data that support the findings of this study are not publicly available due to their containing information that could compromise the privacy of research participants but are available from the corresponding author Shu Hong upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Shu, BMed, Doctor, Chief Doctor, Chief Physician, MHSc, Professor, Senior Consultant Dermatologist, Staff Physician, Department of Dermatology, Kunming Children’s Hospital, No. 288 Qianxing Road, Xishan District, Kunming 650000, Yunnan Province, China. etyyshuhong@sina.com
Received: February 3, 2023
Peer-review started: February 3, 2023
First decision: April 10, 2023
Revised: April 23, 2023
Accepted: May 6, 2023
Article in press: May 6, 2023
Published online: June 16, 2023
Peer-review started: February 3, 2023
First decision: April 10, 2023
Revised: April 23, 2023
Accepted: May 6, 2023
Article in press: May 6, 2023
Published online: June 16, 2023
Core Tip
Core Tip: This study examined the correlation between clinical manifestation and histopathology of pediatric granuloma annulare. We performed a retrospective analysis of thirty-nine cases of granuloma annulare in children and demonstrated a correlation between histopathological staining and elastic fiber dissolution. Different pathological staging may reflect the pathological manifestation of granuloma annulare at different periods. Our study demonstrates that elastic fiber degradation may be a critical step in the pathogenesis of pediatric granuloma annulare. Moreover, it is one of the first studies on granuloma annulare in children.