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World J Clin Cases. Jun 16, 2023; 11(17): 3980-3992
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.3980
Kidney disease in patients with chronic liver disease: Does sex matter?
Katherine M Cooper, Alessandro Colletta, Kristen Moulton, Kenneth M Ralto, Deepika Devuni
Katherine M Cooper, Alessandro Colletta, Department of Medicine, UMass Chan Medical School, Worcester, MA 01665, United States
Kristen Moulton, Deepika Devuni, Department of Medicine, Division of Gastroenterology, UMass Chan Medical School, Worcester, MA 01665, United States
Kenneth M Ralto, Department of Medicine, Division of Renal Medicine, UMass Chan Medical School, Worcester, MA 01665, United States
Author contributions: Cooper KM contributed to conceptualization, preparation, writing, final approval, and final revision of the manuscript; Colletta A and Moulton K contributed to conceptualization, preparation, writing, and final approval of the manuscript; Ralto K and Devuni D contributed to conceptualization, writing, and final approval of the manuscript.
Conflict-of-interest statement: KR receives support from Otsuka Pharmaceutical Development and Commercialization for a clinical trial unrelated to this work. DD receives grant funding from Sequana Medical for a clinical trial unrelated to the present work and grant funding from the NIAAA for research unrelated to this work. All other authors have no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Katherine M Cooper, MD, Doctor, Department of Medicine, UMass Chan Medical School, 55 Lake Ave, Worcester, MA 01665, United States. katherine.cooper@umassmed.edu
Received: March 21, 2023
Peer-review started: March 21, 2023
First decision: April 27, 2023
Revised: April 30, 2023
Accepted: May 16, 2023
Article in press: May 16, 2023
Published online: June 16, 2023
Core Tip

Core Tip: Kidney disease in patients with chronic liver disease is common and associated with increased morbidity and mortality. Most literature on this topic is based in men. However, there are important sex differences to consider in pathophysiology and outcomes in men and women that are poorly addressed in the literature. Here, we synthesize data on sex differences in kidney disease amongst patients with liver disease.