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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 16, 2023; 11(17): 3932-3948
Published online Jun 16, 2023. doi: 10.12998/wjcc.v11.i17.3932
Liver replacement therapy with extracorporeal blood purification techniques current knowledge and future directions
Panagiotis Papamichalis, Katerina G Oikonomou, Asimina Valsamaki, Maria Xanthoudaki, Periklis Katsiafylloudis, Evangelia Papapostolou, Apostolia-Lemonia Skoura, Michail Papamichalis, Marios Karvouniaris, Antonios Koutras, Eleni Vaitsi, Smaragdi Sarchosi, Antonios Papadogoulas, Dimitrios Papadopoulos
Panagiotis Papamichalis, Katerina G Oikonomou, Asimina Valsamaki, Maria Xanthoudaki, Periklis Katsiafylloudis, Evangelia Papapostolou, Eleni Vaitsi, Antonios Papadogoulas, Dimitrios Papadopoulos, Intensive Care Unit, General Hospital of Larissa, Larissa 41221, Thessaly, Greece
Apostolia-Lemonia Skoura, Department of Transfusion Medicine, University Hospital of Larissa, Larissa 41110, Thessaly, Greece
Michail Papamichalis, Department of Cardiology, University Hospital of Larissa, Larissa 41110, Thessaly, Greece
Marios Karvouniaris, Intensive Care Unit, AHEPA University Hospital, Thessaloniki 54636, Greece
Antonios Koutras, 1st Department of Obstetrics and Gynecology, General Hospital of Athens “ALEXANDRA”, National and Kapodistrian University of Athens, Athens 11528, Greece
Smaragdi Sarchosi, Department of Anesthesiology, University Hospital of Larissa, Larissa 41110, Thessaly, Greece
Author contributions: Papamichalis P and Oikonomou KG designed the review; Xanthoudaki M, Katsiafylloudis P, Papapostolou E, Skoura A-L, Papamichalis M, Karvouniaris M, Koutras A, Vaitsi E, Sarchosi S, and Papadogoulas A gathered the data; Papamichalis P, Oikonomou KG, and Valsamaki A analyzed, interpreted the data and wrote the final version of the manuscript; Oikonomou KG performed English editing of the revised manuscript (the original manuscript was edited by a professional English language editing company); Papadopoulos D critically reviewed the paper.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Panagiotis Papamichalis, MD, PhD, Consultant Physician-Scientist, Doctor, Intensive Care Unit, General Hospital of Larissa, 1 Tsakalof, Larissa 41221, Thessaly, Greece. ppapamih@med.uth.gr
Received: February 27, 2023
Peer-review started: February 27, 2023
First decision: April 10, 2023
Revised: May 4, 2023
Accepted: May 12, 2023
Article in press: May 12, 2023
Published online: June 16, 2023
Processing time: 104 Days and 8.6 Hours
Core Tip

Core Tip: Elimination of liver toxins during liver failure is a highly difficult and complex process and demands a combination of multiple methods. Although the evolution of artificial extracorporeal systems is remarkable, it is still insufficient to meet the current therapeutic demands. Several methods and circuits are available, each one with different features, advantages, and disadvantages. There is an urgent need for more research, randomized controlled trials, and evidence. Implementation of protocols combining the available techniques in response to each patient’s special needs is probably the key to personalized treatment, as bridging therapy either to recovery or to liver transplantation.