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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2023; 11(16): 3765-3779
Published online Jun 6, 2023. doi: 10.12998/wjcc.v11.i16.3765
Published online Jun 6, 2023. doi: 10.12998/wjcc.v11.i16.3765
Hypoperfusion context as a predictor of 28-d all-cause mortality in septic shock patients: A comparative observational study
Sahil Kataria, Omender Singh, Deven Juneja, Amit Goel, Madhura Bhide, Devraj Yadav, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India
Author contributions: Kataria S, Singh O, and Juneja D designed the study; Kataria S, Bhide M, and Yadav D collected the data and analyzed the results; Kataria S and Juneja D performed the majority of the writing and prepared the tables; Singh O, Goel A, Devraj Y, and Bhide M provided input in writing the paper and reviewed the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Max Super Specialty Hospital, Saket, Institutional Review Board (Approval No. TS/MSSH/MHIL/SKT-1/MHEC/CC/20-14).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deven Juneja, DNB, Director, Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, 1, Press Enclave Road, New Delhi 110017, India.
Received: November 30, 2022
Peer-review started: November 30, 2022
First decision: January 17, 2023
Revised: January 17, 2023
Accepted: April 18, 2023
Article in press: April 18, 2023
Published online: June 6, 2023
Processing time: 183 Days and 17.5 Hours
Peer-review started: November 30, 2022
First decision: January 17, 2023
Revised: January 17, 2023
Accepted: April 18, 2023
Article in press: April 18, 2023
Published online: June 6, 2023
Processing time: 183 Days and 17.5 Hours
Core Tip
Core Tip: Two different clinical patterns among hyperlactatemic septic shock patients can be effectively differentiated when utilizing three easily employable perfusion parameters. Lactate levels are still the best available tool, but persistence of high central venous-arterial PCO2 gradient (> 6 mmHg) or raised capillary refill time (> 4 s) at 3 h and 6 h along with lactate metrics during early resuscitation can be valuable for guiding resuscitation of septic shock patients.