Minireviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2023; 11(15): 3408-3417
Published online May 26, 2023. doi: 10.12998/wjcc.v11.i15.3408
Synchronous manifestation of colorectal cancer and intraductal papillary mucinous neoplasms
Milko Bozhidarov Mirchev, Irina Boeva, Monika Peshevska-Sekulovska, Veselin Stoitsov, Milena Peruhova
Milko Bozhidarov Mirchev, Irina Boeva, Veselin Stoitsov, Milena Peruhova, Department of Gastroenterology, Heart and Brain Hospital, Burgas 8000, Bulgaria
Monika Peshevska-Sekulovska, Department of Gastroenterology, University Hospital Lozenetz, Sofia 1407, Bulgaria
Author contributions: Mirchev M and Peruhova M wrote the majority of the manuscript; Boeva I and Peshevska-Sekulovska M prepared the figures and tables; Stoitsov V provided critical revision, designed the outline of the manuscript, and coordinated the writing of the paper.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Milena Peruhova, MD, Assistant Professor, Department of Gastroenterology, Heart and Brain Hospital, Zdrave 1 st, Burgas 8000, Bulgaria. mperuhova@gmail.com
Received: January 10, 2023
Peer-review started: January 10, 2023
First decision: February 8, 2023
Revised: February 26, 2023
Accepted: April 17, 2023
Article in press: April 17, 2023
Published online: May 26, 2023
Processing time: 134 Days and 19.4 Hours
Core Tip

Core Tip: In this mini-review, we highlighted the genetic alterations that occur in intraductal papillary mucinous neoplasm (IPMN) and colorectal cancer to understand common genetic or epigenetic risk factors that could explain their synchronous manifestation. The process of malignant transformation in both entities is complex, but some distinctive features of IPMN lesions are linked with their genetic heterogeneity. Specific mutations in GNAS and KRAS are mainly expressed in IPMN. A significantly lower frequency of mutations is detected in other cancer-related genes, such as SMAD4, PI3KCA, PTEN, and BRAF.